SH3GLB2 - SH3 domain containing GRB2 like, endophilin B2 Gene

Also Known as RRIG1; PP6569; PP9455

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56904

About SH3GLB2

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,007,036-129,028,331 (from NCBI)

This gene has 12 transcripts (splice variants), 274 orthologues and 12 paralogues. Ubiquitous expression in skin (RPKM 45.1), prostate (RPKM 29.7) and 25 other tissues.

Summary

Enables identical protein binding activity. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SH3GLB2 Products (6)

mRNA Protein Name
NM_001287045.2 NP_001273974.1 endophilin-B2 isoform a
NM_001287046.2 NP_001273975.1 endophilin-B2 isoform b
NM_001369913.1 NP_001356842.1 endophilin-B2 isoform c
NM_001369914.1 NP_001356843.1 endophilin-B2 isoform d
NM_001369915.1 NP_001356844.1 endophilin-B2 isoform e
NM_020145.4 NP_064530.1 endophilin-B2 isoform b

SH3GLB2 Protein Structure

BAR

BAR: BAR domain (16 - 279)

SH3_9

SH3_9: Variant SH3 domain (342 - 392)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
Protein Preferred Names Protein Names

endophilin-B2

  • SH3 domain-containing GRB2-like protein B2

SH3GLB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SH3GLB2 Q9NR46 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32296183
Intra
SH3GLB2 Q9NR46 SH3GLB1 Homo sapiens Q9Y371
MAPPIT
25416956
Intra
SH3GLB2 Q9NR46 SH3GLB1 Homo sapiens Q9Y371
Anti Tag CoIP
35271311
Intra
SH3GLB2 Q9NR46 SH3GLB1 Homo sapiens Q9Y371
Anti Tag CoIP
20562859
Intra
SH3GLB2 Q9NR46 SH3GLB1 Homo sapiens Q9Y371
BFG-2H
27107012
Intra
SH3GLB2 Q9NR46 SH3GLB1 Homo sapiens Q9Y371
Anti Tag CoIP
33961781
Intra
SH3GLB2 Q9NR46 TBC1D7 Homo sapiens Q9P0N9
Validated Y2H
32296183
Intra
SH3GLB2 Q9NR46 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
SH3GLB2 Q9NR46 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra
SH3GLB2 Q9NR46 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra
SH3GLB2 Q9NR46 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra
SH3GLB2 Q9NR46 MAGEA1 Homo sapiens P43355
BFG-2H
27107012
Intra
SH3GLB2 Q9NR46 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epidermolysis Bullosa Simplex 5b, With Muscular Dystrophy

  • Epidermolysis Bullosa Simplex With Muscular Dystrophy

  • Md-Ebs

  • Epidermolysis Bullosa Simplex And Limb-Girdle Muscular Dystrophy

  • EBS5B

  • Ebsmd

  • Mdebs

  • Limb-Girdle Muscular Dystrophy With Epidermolysis Bullosa Simplex

  • Ebs-Md

  • Epidermolysa Bullosa Simplex And Limb Girdle Muscular Dystrophy

  • Epidermolysa Bullosa Simplex With Muscular Dystrophy

  • Epidermolysis Bullosa Simplex - Limb Girdle Muscular Dystrophy

  • Ebs With Muscular Dystrophy

  • Muscular Dystrophy With Epidermolysis Bullosa Simplex

  • Epidermolysa Bullosa Simplex, With Muscular Dystrophy
Epidermolysis Bullosa, Junctional 5b, With Pyloric Atresia

  • Junctional Epidermolysis Bullosa With Pyloric Atresia

  • Carmi Syndrome

  • Epidermolysis Bullosa, Junctional, With Pyloric Atresia

  • Jeb-Pa

  • JEB5B

  • Epidermolysis Bullosa Junctionalis With Pyloric Atresia

  • Aplasia Cutis Congenita With Gastrointestinal Atresia

  • Epidermolysis Bullosa, Junctional, With Pyloric Atresia And Aplasia Cutis Congenita

  • Eb-Pa-Acc

  • Junctional Epidermolysis Bullosa-Pyloric Atresia Syndrome

  • Jeb With Pyloric Atresia

  • Epidermolysis Bullosa Letalis, With Pyloric Atresia

  • Pa-Jeb

  • Epidermolysis Bullosa With Pyloric Atresia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12840 SH3GLB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SH3GLB2 VGNC VGNC:46128
Rattus norvegicus SH3GLB2 RGD RGD:1305886
Macaca mulatta SH3GLB2 VGNC VGNC:77207
Mus musculus SH3GLB2 MGD MGI:2385131
Felis catus SH3GLB2 VGNC VGNC:65110
Bos taurus SH3GLB2 VGNC VGNC:34576
Others SH3GLB2 NCBI