TPD52L2 - TPD52 like 2 Gene

Also Known as D54; TPD54

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7165

About TPD52L2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,865,270-63,891,538 (from NCBI)

This gene has 10 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 35.6), bone marrow (RPKM 34.4) and 25 other tissues.

Summary

This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with Other tumor protein D52-like proteins. Expression of this gene may be a marker for breast Cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]

TPD52L2 Products (10)

mRNA Protein Name
NM_001243891.2 NP_001230820.1 tumor protein D54 isoform g
NM_001243892.2 NP_001230821.1 tumor protein D54 isoform h
NM_001243894.2 NP_001230823.1 tumor protein D54 isoform i
NM_001243895.2 NP_001230824.1 tumor protein D54 isoform j
NM_003288.4 NP_003279.2 tumor protein D54 isoform e
NM_199359.3 NP_955391.1 tumor protein D54 isoform f
NM_199360.3 NP_955392.1 tumor protein D54 isoform a
NM_199361.3 NP_955393.1 tumor protein D54 isoform b
NM_199362.3 NP_955394.1 tumor protein D54 isoform c
NM_199363.3 NP_955395.1 tumor protein D54 isoform d

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9484778 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9484778 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16112108 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16112108 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPD52L2 Protein Structure

TPD52

TPD52: Tumour protein D52 family (34 - 198)

  • 0
  • 100
  • 206 a.a.
Protein Preferred Names Protein Names

tumor protein D54

  • HCCR-binding protein 2

TPD52L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TPD52L2 O43399 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32296183
Intra
TPD52L2 O43399 ABHD5 Homo sapiens Q8WTS1
Validated Y2H
32296183
Intra
TPD52L2 O43399 ABHD5 Homo sapiens Q8WTS1
Y2H Prey Pooling
32296183
Intra
TPD52L2 O43399 ABHD5 Homo sapiens Q8WTS1
Y2H Array
32296183
Intra
TPD52L2 O43399 COQ8A Homo sapiens Q8NI60
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

TPD52L2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811181 TPD52L2 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14930 TPD52L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TPD52L2 VGNC VGNC:47735
Rattus norvegicus TPD52L2 RGD RGD:735167
Bos taurus TPD52L2 VGNC VGNC:36246
Macaca mulatta TPD52L2 VGNC VGNC:98462
Mus musculus TPD52L2 MGD MGI:1913564
Felis catus TPD52L2 VGNC VGNC:66472
Others TPD52L2 NCBI