Amb123203
Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds.
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- Pureza : 98.87%
- No. CAS: 956571-77-0
- Fòrmula: C25H27N5OS
- Peso molecular:445.58
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 956571-77-0
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Appearance Solid
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Peso molecular 445.58
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Fòrmula C25H27N5OS
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Color Off-white to light yellow
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SMILES
O=C(CN1CCCC(C1)C2=NC3=C(S2)C=CC=C3)NC4=C(C)N(C5=CC=CC=C5)N=C4C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : ≥ 100 mg/mL (224.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2443 mL | 11.2213 mL | 22.4427 mL | 56.1066 mL |
| 5 mM | 0.4489 mL | 2.2443 mL | 4.4885 mL | 11.2213 mL | |
| 10 mM | 0.2244 mL | 1.1221 mL | 2.2443 mL | 5.6107 mL | |
| 15 mM | 0.1496 mL | 0.7481 mL | 1.4962 mL | 3.7404 mL | |
| 20 mM | 0.1122 mL | 0.5611 mL | 1.1221 mL | 2.8053 mL | |
| 25 mM | 0.0898 mL | 0.4489 mL | 0.8977 mL | 2.2443 mL | |
| 30 mM | 0.0748 mL | 0.3740 mL | 0.7481 mL | 1.8702 mL | |
| 40 mM | 0.0561 mL | 0.2805 mL | 0.5611 mL | 1.4027 mL | |
| 50 mM | 0.0449 mL | 0.2244 mL | 0.4489 mL | 1.1221 mL | |
| 60 mM | 0.0374 mL | 0.1870 mL | 0.3740 mL | 0.9351 mL | |
| 80 mM | 0.0281 mL | 0.1403 mL | 0.2805 mL | 0.7013 mL | |
| 100 mM | 0.0224 mL | 0.1122 mL | 0.2244 mL | 0.5611 mL |
Amb123203 Related Classifications
HY-122046 Related Classifications
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