LDLRAD4 - low density lipoprotein receptor class A domain containing 4 Gene

Also Known as C18orf1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 753

About LDLRAD4

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:13,217,682-13,652,754 (from NCBI)

This gene has 40 transcripts (splice variants), 224 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 2.9), prostate (RPKM 1.4) and 24 other tissues.

Summary

Enables R-SMAD binding activity. Involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

LDLRAD4 Products (16)

mRNA Protein Name
NM_001003674.3 NP_001003674.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform gamma 1
NM_001003675.3 NP_001003675.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform gamma 2
NM_001276249.1 NP_001263178.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform delta 1
NM_001276251.2 NP_001263180.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform epsilon 1
NM_001378098.1 NP_001365027.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_001378099.1 NP_001365028.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_001378100.1 NP_001365029.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_001378101.1 NP_001365030.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2
NM_001394662.1 NP_001381591.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_001394663.1 NP_001381592.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_001394664.1 NP_001381593.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2
NM_001394665.1 NP_001381594.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2
NM_001394666.1 NP_001381595.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform 15
NM_001394667.1 NP_001381596.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform 15
NM_181481.5 NP_852146.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1
NM_181482.5 NP_852147.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables R-SMAD binding IPI
IPI: Inferred from physical interaction
24627487 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24627487 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
24627487 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
24627487 GOA
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
24627487 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
24627487 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24627487 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
24627487 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDLRAD4 Protein Structure

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (16 - 47)

  • 0
  • 100
  • 200
  • 306 a.a.
Protein Preferred Names Protein Names

low-density lipoprotein receptor class A domain-containing protein 4

  • clone 22

LDLRAD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LDLRAD4 O15165 NEDD4 Homo sapiens P46934
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07579 LDLRAD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LDLRAD4 VGNC VGNC:74038
Rattus norvegicus LDLRAD4 RGD RGD:1587105
Felis catus LDLRAD4 VGNC VGNC:80448
Mus musculus LDLRAD4 MGD MGI:1277150
Bos taurus LDLRAD4 VGNC VGNC:30829
Canis familiaris LDLRAD4 VGNC VGNC:42625
Others LDLRAD4 NCBI