MMRi6
Based on 1 Customer Validation
MMRi6 is a Mdm2-MdmX RING domain inhibitor that can disrupt Mdm2-MdmX RING-RING interaction in vitro. MMRi6 inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated p53 polyubiquitination in vitro without affecting NEDD4-1 autoubiquitination. MMRi6 induces p53 stabilization and accumulation and induces PARP cleavage in wt-p53 Emu-myc lymphoma cells. MMRi6 inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells with IC50s of approximately 0.5 μM and 3 μM, respectively. MMRi6 can be used for the study of leukemia/lymphoma.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 709009-15-4
- Formula: C21H15Cl2N3O
- Molecular Weight:396.27
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
MMRi6 (10 μM) inhibits Mdm2 autoubiquitination and p53 ubiquitination by Mdm2–MdmX in vitro[1].
MMRi6 (5 μM, 8 h) induces p53 protein accumulation in HCT-8 cells and in wt-p53 Emu-myc lymphoma cells[1].
MMRi6 (0.5 μM, 24 h) induces PARP cleavage in wt-p53 Emu-myc lymphoma cells but not in p53-null Emu-myc lymphoma cells[1].
MMRi6 (0.5-1 μM, 72 h) inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells with IC50s of approximately 0.5 μM and 3 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-8 cells, wt-p53 Emu-myc lymphoma cells and p53-null Emu-myc lymphoma cells
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Concentration:0.5, 5, 10 μM
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Incubation Time:8, 24 h
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Result:Induced p53 protein accumulation in HCT-8 cells and in wt-p53 Emu-myc lymphoma cells.
Induced PARP cleavage in wt-p53 Emu-myc lymphoma cells but not in p53-null Emu-myc lymphoma cells.
Chemical Information
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CAS No. 709009-15-4
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Appearance Solid
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Molecular Weight 396.27
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Formula C21H15Cl2N3O
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Color White to light yellow
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SMILES
OC1=C2N=CC=CC2=C(Cl)C=C1C(C3=CC=CC(Cl)=C3)NC4=NC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 50 mg/mL (126.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5235 mL | 12.6177 mL | 25.2353 mL | 63.0883 mL |
| 5 mM | 0.5047 mL | 2.5235 mL | 5.0471 mL | 12.6177 mL | |
| 10 mM | 0.2524 mL | 1.2618 mL | 2.5235 mL | 6.3088 mL | |
| 15 mM | 0.1682 mL | 0.8412 mL | 1.6824 mL | 4.2059 mL | |
| 20 mM | 0.1262 mL | 0.6309 mL | 1.2618 mL | 3.1544 mL | |
| 25 mM | 0.1009 mL | 0.5047 mL | 1.0094 mL | 2.5235 mL | |
| 30 mM | 0.0841 mL | 0.4206 mL | 0.8412 mL | 2.1029 mL | |
| 40 mM | 0.0631 mL | 0.3154 mL | 0.6309 mL | 1.5772 mL | |
| 50 mM | 0.0505 mL | 0.2524 mL | 0.5047 mL | 1.2618 mL | |
| 60 mM | 0.0421 mL | 0.2103 mL | 0.4206 mL | 1.0515 mL | |
| 80 mM | 0.0315 mL | 0.1577 mL | 0.3154 mL | 0.7886 mL | |
| 100 mM | 0.0252 mL | 0.1262 mL | 0.2524 mL | 0.6309 mL |
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