709009-15-4
Chemical Structure
MMRi6
- CAS No.: 709009-15-4
- Formula:C21H15Cl2N3O
- Molecular Weight:396.27
IUPAC Name: 5-chloro-7-((3-chlorophenyl)(pyridin-2-ylamino)methyl)quinolin-8-ol
InChIKey: QEMVHDDDWVNQAB-UHFFFAOYSA-N
SMILES: OC1=C2N=CC=CC2=C(Cl)C=C1C(C3=CC=CC(Cl)=C3)NC4=NC=CC=C4
Biological Activity: MMRi6 is a Mdm2-MdmX RING domain inhibitor that can disrupt Mdm2-MdmX RING-RING interaction in vitro. MMRi6 inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated p53 polyubiquitination in vitro without affecting NEDD4-1 autoubiquitination. MMRi6 induces p53 stabilization and accumulation and induces PARP cleavage in wt-p53 Emu-myc lymphoma cells. MMRi6 inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells with IC50s of approximately 0.5 μM and 3 μM, respectively. MMRi6 can be used for the study of leukemia/lymphoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MMRi6 | 99.70% | MMRi6 is a Mdm2-MdmX RING domain inhibitor that can disrupt Mdm2-MdmX RING-RING interaction in vitro. MMRi6 inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated p53 polyubiquitination in vitro without affecting NEDD4-1 autoubiquitination. MMRi6 induces p53 stabilization and accumulation and induces PARP cleavage in wt-p53 Emu-myc lymphoma cells. MMRi6 inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells with IC50s of approximately 0.5 μM and 3 μM, respectively. MMRi6 can be used for the study of leukemia/lymphoma. | ||||||||||||||||||||
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Keywords
