FOXN1 Antibody
(Synonyms: FKHL20; RONU; TIDAND; TLIND; WHN; FOXN1_HUMAN; FOXN1; Winged-helix transcription factor nude; forkhead box N1; winged-helix nude; Rowett nude)FOXN1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to FOXN1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, FC, IF-Tissue
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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FC
FC: Flow Cytometry
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:100-500 | 1:50-200 | 1ug/Test |
Product Details
FOXN1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to FOXN1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 69 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 69 kDa
KLH conjugated synthetic peptide derived from human FOXN1 : 321-420/648.
Endogenous
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FOXN1 is a transcription factor that regulates the development, differentiation, and function of thymic epithelial cells (TECs) in the prenatal and postnatal thymus. As the master regulator of TEC lineage development, FOXN1 is required throughout the entire process, from the differentiation of progenitor TEC cells in the developing fetus to TEC maturation and acquisition of full function. FOXN1 directly or indirectly regulates the expression of multiple genes that mediate various aspects of thymus development and function, including MHC class II molecules, DLL4, CCL25, CTSL, CD40, and PAX1. FOXN1 regulates the differentiation of immature thymic epithelial cells (TECs) into functional cortical thymic epithelial cells (cTECs) and medullary thymic epithelial cells (mTECs). FOXN1 is crucial for maintaining the number of mTECs in the thymus after birth. It participates in the morphogenesis and maintenance of the thymic three-dimensional microstructure, which is essential for the full functioning of the thymus. It plays an important role in maintaining hematopoietic function, particularly in maintaining T cell lineage progenitor cells in the bone marrow microenvironment as the thymus ages. FOXN1 is essential for the vascularization of thymic primordia. It plays a key role in the early prenatal stages of T cell development.
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Subcellular Localization
Nucleus
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Expression
Tissue specificity: Expressed in thymus. -
SwissProt ID
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Synonyms
FKHL20; RONU; TIDAND; TLIND; WHN; FOXN1_HUMAN; FOXN1; Winged-helix transcription factor nude; forkhead box N1; winged-helix nude; Rowett nude
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Research Field
Cell Biology
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