PRMT7 - protein arginine methyltransferase 7 Gene

Also Known as SBIDDS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54496

About PRMT7

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,311,019-68,360,870 (from NCBI)

This gene has 55 transcripts (splice variants), 206 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in small intestine (RPKM 5.3), testis (RPKM 5.1) and 25 other tissues.

Summary

This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as Other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and Other features. The encoded protein may promote breast Cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]

PRMT7 Products (64)

mRNA	Protein	Name
XM_017023292.3	XP_016878781.1	protein arginine N-methyltransferase 7 isoform X2
XM_011523112.4	XP_011521414.1	protein arginine N-methyltransferase 7 isoform X1
XM_011523121.4	XP_011521423.1	protein arginine N-methyltransferase 7 isoform X9
XM_047434235.1	XP_047290191.1	protein arginine N-methyltransferase 7 isoform X17
XM_011523116.4	XP_011521418.1	protein arginine N-methyltransferase 7 isoform X2
XM_047434226.1	XP_047290182.1	protein arginine N-methyltransferase 7 isoform X9
NM_001378020.1	NP_001364949.1	protein arginine N-methyltransferase 7 isoform 10
NR_147058.3
XR_007064885.1
XM_047434232.1	XP_047290188.1	protein arginine N-methyltransferase 7 isoform X15
NM_001351143.3	NP_001338072.1	protein arginine N-methyltransferase 7 isoform 4
XM_047434236.1	XP_047290192.1	protein arginine N-methyltransferase 7 isoform X18
XM_047434227.1	XP_047290183.1	protein arginine N-methyltransferase 7 isoform X10
XR_007064888.1
NR_165369.1
XR_002957814.2
XM_047434233.1	XP_047290189.1	protein arginine N-methyltransferase 7 isoform X16
NM_001378018.1	NP_001364947.1	protein arginine N-methyltransferase 7 isoform 1
XM_047434220.1	XP_047290176.1	protein arginine N-methyltransferase 7 isoform X5
XM_047434224.1	XP_047290180.1	protein arginine N-methyltransferase 7 isoform X8
XM_017023301.3	XP_016878790.1	protein arginine N-methyltransferase 7 isoform X12
XM_017023296.3	XP_016878785.1	protein arginine N-methyltransferase 7 isoform X4
XM_047434229.1	XP_047290185.1	protein arginine N-methyltransferase 7 isoform X12
NM_001290018.2	NP_001276947.1	protein arginine N-methyltransferase 7 isoform 1
XR_007064887.1
NR_147057.3
XM_047434230.1	XP_047290186.1	protein arginine N-methyltransferase 7 isoform X13
NM_001184824.4	NP_001171753.1	protein arginine N-methyltransferase 7 isoform 2
XM_047434222.1	XP_047290178.1	protein arginine N-methyltransferase 7 isoform X5
NR_165373.1
NR_165365.1
NR_147056.3
XM_017023300.3	XP_016878789.1	protein arginine N-methyltransferase 7 isoform X11
XM_047434239.1	XP_047290195.1	protein arginine N-methyltransferase 7 isoform X21
XM_017023297.3	XP_016878786.1	protein arginine N-methyltransferase 7 isoform X5
XM_017023304.3	XP_016878793.1	protein arginine N-methyltransferase 7 isoform X14
XM_017023299.3	XP_016878788.1	protein arginine N-methyltransferase 7 isoform X8
XM_047434234.1	XP_047290190.1	protein arginine N-methyltransferase 7 isoform X17
NR_165366.1
NM_001378021.1	NP_001364950.1	protein arginine N-methyltransferase 7 isoform 11
XR_001751915.3
XM_047434219.1	XP_047290175.1	protein arginine N-methyltransferase 7 isoform X3
XM_047434231.1	XP_047290187.1	protein arginine N-methyltransferase 7 isoform X15
NR_165370.1
XM_047434225.1	XP_047290181.1	protein arginine N-methyltransferase 7 isoform X9
NR_165368.1
XM_047434217.1	XP_047290173.1	protein arginine N-methyltransferase 7 isoform X1
XM_017023298.3	XP_016878787.1	protein arginine N-methyltransferase 7 isoform X6
XR_007064886.1
NM_019023.5	NP_061896.1	protein arginine N-methyltransferase 7 isoform 1
XM_047434237.1	XP_047290193.1	protein arginine N-methyltransferase 7 isoform X19
XM_047434218.1	XP_047290174.1	protein arginine N-methyltransferase 7 isoform X2
XM_011523113.4	XP_011521415.1	protein arginine N-methyltransferase 7 isoform X1
XM_047434238.1	XP_047290194.1	protein arginine N-methyltransferase 7 isoform X20
XM_047434228.1	XP_047290184.1	protein arginine N-methyltransferase 7 isoform X12
XM_047434221.1	XP_047290177.1	protein arginine N-methyltransferase 7 isoform X5
XM_011523115.4	XP_011521417.1	protein arginine N-methyltransferase 7 isoform X1
NM_001351144.3	NP_001338073.1	protein arginine N-methyltransferase 7 isoform 5
NR_165367.1
NR_165372.1
NM_001378022.1	NP_001364951.1	protein arginine N-methyltransferase 7 isoform 11
NM_001378023.1	NP_001364952.1	protein arginine N-methyltransferase 7 isoform 11
NR_165371.1
XM_047434223.1	XP_047290179.1	protein arginine N-methyltransferase 7 isoform X7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables S-adenosylmethionine-dependent methyltransferase activity	IDA IDA: Inferred from direct assay	15044439	GOA
enables histone H4 methyltransferase activity	IDA IDA: Inferred from direct assay	15494416	GOA
enables histone binding	IDA IDA: Inferred from direct assay	15494416	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28587924	GOA
enables protein-arginine omega-N monomethyltransferase activity	IDA IDA: Inferred from direct assay	15044439	GOA
enables protein-arginine omega-N symmetric methyltransferase activity	IDA IDA: Inferred from direct assay	15494416	GOA
enables protein-arginine omega-N symmetric methyltransferase activity	IMP IMP: Inferred from mutant phenotype	17709427	GOA
enables ribonucleoprotein complex binding	IPI IPI: Inferred from physical interaction	17709427	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in peptidyl-arginine methylation	IDA IDA: Inferred from direct assay	15044439	GOA
involved in peptidyl-arginine methylation	IMP IMP: Inferred from mutant phenotype	17709427	GOA
involved in spliceosomal snRNP assembly	IMP IMP: Inferred from mutant phenotype	17709427	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	15494416	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15494416	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT7 Protein Structure

PrmA

0
200
400
600
692 a.a.

Protein Preferred Names	Protein Names
protein arginine N-methyltransferase 7	[Myelin basic protein]-arginine N-methyltransferase PRMT7 histone-arginine N-methyltransferase PRMT7

PRMT7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRMT7	Q9NVM4	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	PRMT7	Q9NVM4	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	PRMT7	Q9NVM4	EIF2S1	Homo sapiens	P05198	Y2H Array	32296183
Intra	PRMT7	Q9NVM4	EIF2S1	Homo sapiens	P05198	Y2H Prey Pooling	32296183
Intra	PRMT7	Q9NVM4	ZNF438	Homo sapiens	Q7Z4V0	Y2H Array	32296183
Intra	PRMT7	Q9NVM4	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
Intra	PRMT7	Q9NVM4	ASS1	Homo sapiens	P00966	Pull Down	28587924
Intra	PRMT7	Q9NVM4	ASS1	Homo sapiens	P00966	Y2H	28587924
Intra	PRMT7	Q9NVM4	ASS1	Homo sapiens	P00966	Confocal	28587924
Intra	PRMT7	Q9NVM4	ASS1	Homo sapiens	P00966	Anti Bait CoIP	28587924
Intra	PRMT7	Q9NVM4	ASS1	Homo sapiens	P00966	Anti Tag CoIP	28587924

Cross: Cross-species interaction Intra: Intraspecies interaction

PRMT7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81989	PRMT7 Antibody (YA1734)	WB	Human, Mouse, Rat
HY-P81989A	PRMT7 Antibody (YA1734)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Primary Bone Dysplasia	Primary Osteodysplasia Primary Skeletal Dysplasia
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Osteochondrodysplasia	Chondrodystrophy Skeletal Dysplasia Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Acanthosis Nigricans	Keratosis Nigricans An
Fatty Liver Disease, Nonalcoholic 1	NAFLD1 Hepatic Steatosis Fatty Liver Disease, Nonalcoholic, Susceptibility To, 1 Non-Alcoholic Fatty Liver Disease 1 Fatty Liver Steatohepatitis
Short Stature, Brachydactyly, Impaired Intellectual Development, And Seizures	SBIDDS Short Stature, Brachydactyly, Intellectual Developmental Disability, And Seizures Short Stature-Brachydactyly-Obesity-Global Developmental Delay Syndrome Short Stature, Brachydactyly, Impaired Intellectual Developmental, And Seizures
Coffin-Siris Syndrome 9	Mrd27 CSS9 Mental Retardation, Autosomal Dominant 27 Autosomal Dominant Mental Retardation 27 Autosomal Dominant Non-Syndromic Intellectual Disability 27 Coffin-Siris Syndrome, Type 9
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Brachydactyly
Autosomal Recessive Disease	Autosomal Recessive Disorder
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Renal Hypoplasia
Epilepsy, Progressive Myoclonic, 12	EPM12 Epilepsy, Progressive Myoclonic 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112445	SGC3027	Inhibitor	98.06%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-124131	DS-437	Inhibitor	99.22%	Unkown
HY-114211	SGC8158	Inhibitor	97.6%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-175821	PRMT1-IN-3	Inhibitor	/	Unkown
HY-111367	MS2734	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRMT7	VGNC	VGNC:64362
Rattus norvegicus	PRMT7	RGD	RGD:1304869
Bos taurus	PRMT7	VGNC	VGNC:33352
Macaca mulatta	PRMT7	VGNC	VGNC:76315
Canis familiaris	PRMT7	VGNC	VGNC:45000
Mus musculus	PRMT7	MGD	MGI:2384879
Others	PRMT7	NCBI