1. Epigenetics
  2. Histone Methyltransferase
  3. SGC3027

SGC3027 

Cat. No.: HY-112445 Purity: 98.52%
Handling Instructions

SGC3027 is a histone methyltransferase inhibitor. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7.

For research use only. We do not sell to patients.

SGC3027 Chemical Structure

SGC3027 Chemical Structure

Size Price Stock Quantity
1 mg USD 170 In-stock
Estimated Time of Arrival: December 31
5 mg USD 600 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE SGC3027

    SGC3027 purchased from MCE. Usage Cited in: Nat Commun. 2021 Mar 29;12(1):1946.

    EZM2302 (10 μM), GSK591 (10 μM), or SGC3027 (10 μM) treatment alone for 24 h changed alternative splicing events commonly regulated by PRMT4, 5, and 7, and their co-treatment exhibited more drastic effects in all three cell lines, namely MCF7, HCT 116, and LNCaP.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SGC3027 is a histone methyltransferase inhibitor[1]. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7[2].

    IC50 & Target

    PRMT7[1][2]

    In Vitro

    SGC3027 is a pro-drug of SGC8158 which releases the active component upon reduction in the cell by reductases. In cellular assays using C2C12 cells, SGC3027 inhibits the methylation of HSP70 with IC50=1.3 μM[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    787.37

    Formula

    C₄₁H₄₇ClN₆O₆S

    SMILES

    ClC1=CC=C(C2=CC(CN(C(CC(C)(C)C3=C(C)C(C(C)=C(C)C3=O)=O)=O)CCCCSC[[email protected]@H]4[[email protected]@H](O)[[email protected]@H](O)[[email protected]](N5C(N=CN=C6N)=C6N=C5)O4)=CC=C2)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 250 mg/mL (317.51 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2701 mL 6.3503 mL 12.7005 mL
    5 mM 0.2540 mL 1.2701 mL 2.5401 mL
    10 mM 0.1270 mL 0.6350 mL 1.2701 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 98.52%

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    Keywords:

    SGC3027SGC 3027SGC-3027Histone MethyltransferaseInhibitorinhibitorinhibit

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    Product Name:
    SGC3027
    Cat. No.:
    HY-112445
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