1. Epigenetics
  2. Histone Methyltransferase
  3. SGC3027

SGC3027 

Cat. No.: HY-112445 Purity: 98.52%
Handling Instructions

SGC3027 is a histone methyltransferase inhibitor. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7.

For research use only. We do not sell to patients.

SGC3027 Chemical Structure

SGC3027 Chemical Structure

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 1472 In-stock
Estimated Time of Arrival: December 31
1 mg USD 170 In-stock
Estimated Time of Arrival: December 31
5 mg USD 600 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SGC3027 is a histone methyltransferase inhibitor[1]. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7[2].

IC50 & Target

PRMT7[1][2]

In Vitro

SGC3027 is a pro-drug of SGC8158 which releases the active component upon reduction in the cell by reductases. In cellular assays using C2C12 cells, SGC3027 inhibits the methylation of HSP70 with IC50=1.3 μM[2].

Molecular Weight

787.37

Formula

C₄₁H₄₇ClN₆O₆S

SMILES

ClC1=CC=C(C2=CC(CN(C(CC(C)(C)C3=C(C)C(C(C)=C(C)C3=O)=O)=O)CCCCSC[[email protected]@H]4[[email protected]@H](O)[[email protected]@H](O)[[email protected]](N5C(N=CN=C6N)=C6N=C5)O4)=CC=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (317.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2701 mL 6.3503 mL 12.7005 mL
5 mM 0.2540 mL 1.2701 mL 2.5401 mL
10 mM 0.1270 mL 0.6350 mL 1.2701 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.52%

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Keywords:

SGC3027SGC 3027SGC-3027Histone MethyltransferaseInhibitorinhibitorinhibit

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SGC3027
Cat. No.:
HY-112445
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