1. Epigenetics
  2. Histone Methyltransferase
  3. SGC3027

SGC3027 

Cat. No.: HY-112445 Purity: >98.0%
Handling Instructions

SGC3027 is a histone methyltransferase inhibitor. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7.

For research use only. We do not sell to patients.

SGC3027 Chemical Structure

SGC3027 Chemical Structure

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Description

SGC3027 is a histone methyltransferase inhibitor[1]. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7[2].

IC50 & Target

PRMT7[1][2]

In Vitro

SGC3027 is a pro-drug of SGC8158 which releases the active component upon reduction in the cell by reductases. In cellular assays using C2C12 cells, SGC3027 inhibits the methylation of HSP70 with IC50=1.3 μM[2].

Molecular Weight

787.37

Formula

C₄₁H₄₇ClN₆O₆S

SMILES

ClC1=CC=C(C2=CC(CN(C(CC(C)(C)C3=C(C)C(C(C)=C(C)C3=O)=O)=O)CCCCSC[[email protected]@H]4[[email protected]@H](O)[[email protected]@H](O)[[email protected]](N5C(N=CN=C6N)=C6N=C5)O4)=CC=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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SGC3027
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HY-112445
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