2. Epigenetics
  3. Histone Methyltransferase
  4. SGC3027

SGC3027 is a histone methyltransferase inhibitor. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7.

For research use only. We do not sell to patients.

SGC3027 Chemical Structure

SGC3027 Chemical Structure

CAS No. : 2624313-13-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 In-stock
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Solid
5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 550 In-stock
50 mg USD 950 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

SGC3027 Related Antibodies

Top Publications Citing Use of Products

    SGC3027 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Mar 29;12(1):1946.  [Abstract]

    EZM2302 (10 μM), GSK591 (10 μM), or SGC3027 (10 μM) treatment alone for 24 h changed alternative splicing events commonly regulated by PRMT4, 5, and 7, and their co-treatment exhibited more drastic effects in all three cell lines, namely MCF7, HCT 116, and LNCaP.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SGC3027 is a histone methyltransferase inhibitor[1]. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7[2].

    IC50 & Target

    PRMT7

     

    In Vitro

    SGC3027 is a pro-drug of SGC8158 which releases the active component upon reduction in the cell by reductases.? In cellular assays using C2C12 cells, SGC3027 inhibits the methylation of HSP70 with IC50=1.3 μM[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SGC3027 Related Antibodies
    Molecular Weight

    787.37

    Formula

    C41H47ClN6O6S
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    ClC1=CC=C(C2=CC(CN(C(CC(C)(C)C3=C(C)C(C(C)=C(C)C3=O)=O)=O)CCCCSC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C(N=CN=C6N)=C6N=C5)O4)=CC=C2)C=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 250 mg/mL (317.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2701 mL 6.3503 mL 12.7005 mL
    5 mM 0.2540 mL 1.2701 mL 2.5401 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.08 mg/mL (2.64 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 98.29%

    COA (248 KB) LCMS (265 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.2701 mL 6.3503 mL 12.7005 mL 31.7513 mL
    5 mM 0.2540 mL 1.2701 mL 2.5401 mL 6.3503 mL
    10 mM 0.1270 mL 0.6350 mL 1.2701 mL 3.1751 mL
    15 mM 0.0847 mL 0.4234 mL 0.8467 mL 2.1168 mL
    20 mM 0.0635 mL 0.3175 mL 0.6350 mL 1.5876 mL
    25 mM 0.0508 mL 0.2540 mL 0.5080 mL 1.2701 mL
    30 mM 0.0423 mL 0.2117 mL 0.4234 mL 1.0584 mL
    40 mM 0.0318 mL 0.1588 mL 0.3175 mL 0.7938 mL
    50 mM 0.0254 mL 0.1270 mL 0.2540 mL 0.6350 mL
    60 mM 0.0212 mL 0.1058 mL 0.2117 mL 0.5292 mL
    80 mM 0.0159 mL 0.0794 mL 0.1588 mL 0.3969 mL
    100 mM 0.0127 mL 0.0635 mL 0.1270 mL 0.3175 mL
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    SGC3027 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SGC30272624313-13-7SGC 3027SGC-3027Histone MethyltransferaseInhibitorinhibitorinhibit

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