ER-beta
Encoded by ESR2 on chromosome 14, estrogen receptor beta shares the domain organization of ER alpha but shows only moderate ligand-binding-domain similarity and a distinct biology. ER beta predominates in ovary granulosa cells, prostate, colon, lung and brain, and generally opposes ER alpha-driven proliferation, promoting differentiation and apoptosis instead. It binds the same estrogen response elements with different affinity and can heterodimerize with ER alpha to modulate its activity; phytoestrogens such as genistein show relative preference for ER beta. Loss of ER beta expression accompanies colorectal and prostate tumor progression, supporting a tumor-suppressive role, and ER beta-selective agonists are being explored for menopausal, inflammatory and neurodegenerative indications without uterine or breast stimulation.
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ER-beta Recombinant Proteins (1)
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Inhibitors & Agonists (59)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
