TAF11 - TATA-box binding protein associated factor 11 Gene

Also Known as TAF2I; PRO2134; TAFII28; MGC:15243

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6882

About TAF11

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,877,462-34,888,071 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and 14 paralogues. Ubiquitous expression in testis (RPKM 12.6), bone marrow (RPKM 9.8) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

TAF11 Products (2)

mRNA Protein Name
NM_001270488.1 NP_001257417.1 transcription initiation factor TFIID subunit 11 isoform 2
NM_005643.4 NP_005634.1 transcription initiation factor TFIID subunit 11 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables TBP-class protein binding IPI
IPI: Inferred from physical interaction
29111974 GOA
enables nuclear thyroid hormone receptor binding IPI
IPI: Inferred from physical interaction
10744685 GOA
enables nuclear vitamin D receptor binding IPI
IPI: Inferred from physical interaction
10744685 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7729427 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
8670810 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA polymerase II preinitiation complex assembly IPI
IPI: Inferred from physical interaction
27007846 GOA
involved in mRNA transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17884155 GOA
involved in positive regulation by host of viral transcription IDA
IDA: Inferred from direct assay
9108034 GOA
involved in positive regulation of transcription initiation by RNA polymerase II IDA
IDA: Inferred from direct assay
17884155 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus EXP
EXP: Inferred from Experiment
23332750 GOA
part of transcription factor TFIID complex IDA
IDA: Inferred from direct assay
7729427 GOA
part of transcription factor TFIID complex IPI
IPI: Inferred from physical interaction
23332750 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF11 Protein Structure

TAFII28

TAFII28: hTAFII28-like protein conserved region (106 - 194)

  • 0
  • 100
  • 200
  • 211 a.a.
Protein Preferred Names Protein Names

transcription initiation factor TFIID subunit 11

  • TAF(II)28

TAF11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TAF11 Q15544 TAF13 Homo sapiens Q15543
X-Ray Diffraction
9695952
Intra
TAF11 Q15544 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
Intra
TAF11 Q15544 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra
TAF11 Q15544 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra
TAF11 Q15544 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Facioscapulohumeral Muscular Dystrophy 1

  • Facioscapulohumeral Muscular Dystrophy

  • Fshd

  • Landouzy-Dejerine Muscular Dystrophy

  • Muscular Dystrophy, Facioscapulohumeral

  • FSHD1

  • Fshd1a

  • Muscular Dystrophy, Facioscapulohumeral, Type 1a

  • Facioscapulohumeral Muscular Dystrophy Type 1a

  • Fsh Muscular Dystrophy

  • Facioscapulohumeral Muscular Dystrophy 1a

  • Facioscapulohumeral Atrophy

  • Facioscapulohumeral Myopathy

  • Muscular Dystrophy, Facioscapulohumeral, Type 1

  • Facioscapulohumeral Muscular Dystrophy Type 1

  • Landouzy Dejerine Muscular Dystrophy

  • Muscular Dystrophy, Landouzy-Dejerine

  • Fshmd1a

  • Facio-Scapulo-Humeral Dystrophy

  • Facioscapulohumeral Type Progressive Muscular Dystrophy

  • Facioscapuloperoneal Muscular Dystrophy

  • Facioscapulohumeral Dystrophy

  • Fsh Dystrophy

  • Landouzy-Dejerine Dystrophy

  • Landouzy-Dejerine Myopathy

  • Fmd

  • Facioscapulohumeral Muscular Dystrophy-1a

  • Muscular Dystrophy Facioscapulohumeral

  • Dystrophy, Muscular, Facioscapulohumeral

  • Dystrophy, Muscular, Facioscapulohumeral, Type 1

  • Landouzy-Dejerine Disease

  • Landouzy-Déjerine Atrophy

  • Facioscapulohumeral Muscle Dystrophy

  • Fmd - [Facioscapulohumeral Muscular Dystrophy]

  • Fsh - [Facioscapulohumeral Muscular Dystrophy]

  • Fshd - [Facioscapulohumeral Muscular Dystrophy]

  • Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy

  • Landouzy-Déjérine Muscular Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14159 TAF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TAF11 VGNC VGNC:54240
Macaca mulatta TAF11 VGNC VGNC:83477
Felis catus TAF11 VGNC VGNC:102529
Mus musculus TAF11 MGD MGI:1916026
Rattus norvegicus TAF11 RGD RGD:1305626
Canis familiaris TAF11 VGNC VGNC:47074
Others TAF11 NCBI