TAF13 - TATA-box binding protein associated factor 13 Gene

Homo sapiens

Also known as MRT60; TAF2K; TAFII18; TAFII-18; TAF(II)18

Gene ID: 6884 | Gene type: protein coding

About TAF13

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,064,140-109,076,003 (from NCBI)

This gene has 3 transcripts (splice variants), 230 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 23.1), kidney (RPKM 21.3) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]

TAF13 Products(1)

mRNA	Protein	Name
NM_005645.4	NP_005636.1	transcription initiation factor TFIID subunit 13

TAF13 Protein Structure

TFIID-18kDa

0
100
124 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor TFIID subunit 13

TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 60

Mental Retardation, Autosomal Recessive 60	MRT60
Autosomal Recessive Intellectual Developmental Disorder 60

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Dystonia 3, Torsion, X-Linked

X-Linked Dystonia-Parkinsonism	DYT3
Xdp	Lubag
Dystonia-Parkinsonism, X-Linked	Torsion Dystonia-Parkinsonism, Filipino Type
Dyt-Taf1	X-Linked Dystonia-Parkinsonism Syndrome
X-Linked Torsion Dystonia-Parkinsonism Syndrome	Dystonia Musculorum Deformans
X-Linked Dystonia-Parkinsonism/Lubag	Lubag Syndrome
Dystonia-3	Torsion Dystonia-Parkinsonism Filipino Type
X-Linked Torsion Dystonia 3	Dystonia, Torsion, X-Linked, Type 3

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14161	TAF13 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TAF13	RGD	RGD:1305398
Felis catus	TAF13	VGNC	VGNC:80373
Bos taurus	TAF13	VGNC	VGNC:35568
Mus musculus	TAF13	MGD	MGI:1913500
Canis familiaris	TAF13	VGNC	VGNC:47075
Others	TAF13	NCBI

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