KLHL35 - kelch like family member 35 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 283212

Summary

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin Ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Biased expression in testis (RPKM 1.5), brain (RPKM 0.7) and 6 other tissues.

KLHL35 Products (1)

mRNA Protein Name
NM_001039548.3 NP_001034637.2 kelch-like protein 35

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL35 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLHL35 Q6PF15 UBTD2 Homo sapiens Q8WUN7
Validated Y2H
32296183
Intra
KLHL35 Q6PF15 FAM25C Homo sapiens B3EWG5
Y2H Array
32296183
Intra
KLHL35 Q6PF15 FAM25C Homo sapiens B3EWG5
Y2H Prey Pooling
32296183
Intra
KLHL35 Q6PF15 ALAS1 Homo sapiens P13196
Validated Y2H
25416956
Intra
KLHL35 Q6PF15 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
KLHL35 Q6PF15 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
KLHL35 Q6PF15 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra
KLHL35 Q6PF15 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra
KLHL35 Q6PF15 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
Intra
KLHL35 Q6PF15 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra
KLHL35 Q6PF15 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
Intra
KLHL35 Q6PF15 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
KLHL35 Q6PF15 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04369 ENC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown