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RRS1 - ribosome biogenesis regulator 1 homolog Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23212

About RRS1

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:66,429,014-66,430,733 (from NCBI)

This gene has 1 transcript (splice variant) and 174 orthologues.

Summary

Enables 5S rRNA binding activity. Involved in several processes, including mitotic metaphase plate congression; protein localization to nucleolus; and ribosomal large subunit assembly. Located in condensed nuclear chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RRS1 Products (1)

mRNA	Protein	Name
NM_015169.4	NP_055984.1	ribosome biogenesis regulatory protein homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables 5S rRNA binding	IDA IDA: Inferred from direct assay	24120868	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	19465021	GOA
involved in protein localization to nucleolus	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in ribosomal large subunit assembly	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: Inferred from mutant phenotype	24120868	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	19465021	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	19465021	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRS1 Protein Structure

RRS1

0
100
200
300
365 a.a.

Protein Preferred Names	Protein Names
ribosome biogenesis regulatory protein homolog	RRS1 ribosome biogenesis regulator homolog

RRS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	RRS1	Q15050	RPF2	Homo sapiens	Q9H7B2	Anti Tag CoIP	28514442
Intra	RRS1	Q15050	RPF2	Homo sapiens	Q9H7B2	Anti Tag CoIP	33961781
Intra	RRS1	Q15050	APPBP2	Homo sapiens	Q92624	Validated Y2H	25416956
Intra	RRS1	Q15050	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183
Intra	RRS1	Q15050	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956
Intra	RRS1	Q15050	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
Intra	RRS1	Q15050	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	RRS1	Q15050	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RRS1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P811124	RRS1 Antibody	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Flinders Island Spotted Fever	Fisf Thai Tick Typhus
Robinow Syndrome, Autosomal Recessive 1	Robinow Syndrome, Autosomal Recessive Autosomal Recessive Robinow Syndrome Covesdem Syndrome RRS1 Costovertebral Segmentation Defect-Mesomelia Syndrome Rrs Costovertebral Segmentation Defect With Mesomelia, Formerly Covesdem Syndrome, Formerly Costovertebral Segmentation Defect With Mesomelia Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly Robinow, Autosomal Recessive Syndrome, Type 1
Robinow Syndrome, Autosomal Dominant 3	Autosomal Dominant Robinow Syndrome 3 DRS3 Robinow, Autosomal Dominant Syndrome, Type 3
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS12294	RRS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21427	Rrs1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27945	Rrs1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RRS1	RGD	RGD:1311403
Macaca mulatta	RRS1	VGNC	VGNC:77035
Bos taurus	RRS1	VGNC	VGNC:34173
Canis familiaris	RRS1	VGNC	VGNC:45768
Mus musculus	RRS1	MGD	MGI:1929721
Felis catus	RRS1	VGNC	VGNC:64784
Others	RRS1	NCBI