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RNF34 - ring finger protein 34 Gene

Also Known as RFI; RIF; RIFF; hRFI; CARP1; CARP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80196

About RNF34

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,400,118-121,424,348 (from NCBI)

This gene has 11 transcripts (splice variants), 281 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 15.4), lymph node (RPKM 13.4) and 25 other tissues.

Summary

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of Apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced Apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by Caspase-3 during the induction of Apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

RNF34 Products (4)

mRNA	Protein	Name
NM_001256858.2	NP_001243787.1	E3 ubiquitin-protein ligase RNF34 isoform 3
NM_001394208.1	NP_001381137.1	E3 ubiquitin-protein ligase RNF34 isoform 1
NM_025126.4	NP_079402.2	E3 ubiquitin-protein ligase RNF34 isoform 2
NM_194271.3	NP_919247.1	E3 ubiquitin-protein ligase RNF34 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables p53 binding	IPI IPI: Inferred from physical interaction	17121812	GOA
enables phosphatidylinositol phosphate binding	IDA IDA: Inferred from direct assay	15069192	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15069192	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	15069192	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	22064484	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18382127	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	15069192	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	15069192	GOA
involved in negative regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17121812	GOA
involved in nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25012219	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15069192	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22064484	GOA
involved in protein K48-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	25012219	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	15069192	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	22064484	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22064484	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15069192	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22064484	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15069192	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF34 Protein Structure

zf-C3HC4_3

0
100
200
300
372 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF34	FYVE-RING finger protein MOMO

RNF34 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF34	Q969K3	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	RNF34	Q969K3	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	RNF34	Q969K3	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	RNF34	Q969K3	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	RNF34	Q969K3	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	RNF34	Q969K3	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	RNF34	Q969K3	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	RNF34	Q969K3	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	RNF34	Q969K3	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	RNF34	Q969K3	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	RNF34	Q969K3	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	RNF34	Q969K3	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	RNF34	Q969K3	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
Intra	RNF34	Q969K3	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
Intra	RNF34	Q969K3	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
Intra	RNF34	Q969K3	PANK2	Homo sapiens	Q9BZ23-2	Y2H Pooling	32814053
Intra	RNF34	Q969K3	PANK2	Homo sapiens	Q9BZ23-2	Validated Y2H	32814053
Intra	RNF34	Q969K3	PANK2	Homo sapiens	Q9BZ23-2	Y2H Array	32814053
Intra	RNF34	Q969K3	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RNF34	Q969K3	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RNF34	Q969K3	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RNF34	Q969K3	APPBP2	Homo sapiens	Q92624	Validated Y2H	25416956
Intra	RNF34	Q969K3	CASP8	Homo sapiens	Q14790	Anti Tag CoIP	15069192

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Patellofemoral Pain Syndrome
Duane Retraction Syndrome	Stilling-Turk-Duane Syndrome Duane'S Syndrome Duane Syndrome Isolated Duane Retraction Syndrome Co-Contractive Retraction Syndrome Duane Anomaly, Isolated Ocular Retraction Syndrome Drs Durs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12087	RNF34 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF34	RGD	RGD:628636
Macaca mulatta	RNF34	VGNC	VGNC:76750
Felis catus	RNF34	VGNC	VGNC:64700
Bos taurus	RNF34	VGNC	VGNC:34063
Mus musculus	RNF34	MGD	MGI:2153340
Canis familiaris	RNF34	VGNC	VGNC:49708
Others	RNF34	NCBI