HIPK4 - homeodomain interacting protein kinase 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 147746

About HIPK4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,379,271-40,390,181 (from NCBI)

This gene has 1 transcript (splice variant), 155 orthologues and 12 paralogues. Restricted expression toward testis (RPKM 7.8).

Summary

This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While Other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to Other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]

HIPK4 Products (1)

mRNA Protein Name
NM_144685.5 NP_653286.2 homeodomain-interacting protein kinase 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIPK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (11 - 347)

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  • 616 a.a.
Protein Preferred Names Protein Names

homeodomain-interacting protein kinase 4

HIPK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HIPK4 Q8NE63 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra
HIPK4 Q8NE63 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
HIPK4 Q8NE63 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

HIPK4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811341 HIPK4 Antibody WB, IHC-P Human

Related Diseases

Diseases Alias
Adenosquamous Lung Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179535 Axl-IN-21 Inhibitor / Unkown
HY-RS06184 HIPK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HIPK4 MGD MGI:2685008
Rattus norvegicus HIPK4 RGD RGD:1307541
Macaca mulatta HIPK4 VGNC VGNC:73421
Bos taurus HIPK4 VGNC VGNC:29861
Felis catus HIPK4 VGNC VGNC:62821
Others HIPK4 NCBI