HIPK4 - homeodomain interacting protein kinase 4 Gene

Homo sapiens

Gene ID: 147746 | Gene type: protein coding

About HIPK4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,379,271-40,390,181 (from NCBI)

This gene has 1 transcript (splice variant), 155 orthologues and 12 paralogues. Restricted expression toward testis (RPKM 7.8).

Summary

This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]

HIPK4 Products(1)

mRNA	Protein	Name
NM_144685.5	NP_653286.2	homeodomain-interacting protein kinase 4

HIPK4 Protein Structure

Pkinase

0
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300
400
500
616 a.a.

Protein Preferred Names

Protein Names

homeodomain-interacting protein kinase 4

Related Diseases

Diseases

Alias

Adenosquamous Lung Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06184	HIPK4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HIPK4	MGD	MGI:2685008
Rattus norvegicus	HIPK4	RGD	RGD:1307541
Macaca mulatta	HIPK4	VGNC	VGNC:73421
Bos taurus	HIPK4	VGNC	VGNC:29861
Felis catus	HIPK4	VGNC	VGNC:62821
Others	HIPK4	NCBI

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