SYT11 - synaptotagmin 11 Gene

Also Known as SYT12; sytXI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23208

About SYT11

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,859,567-155,885,199 (from NCBI)

This gene has 1 transcript (splice variant), 230 orthologues and 31 paralogues. Biased expression in brain (RPKM 160.9), adrenal (RPKM 11.8) and 1 other tissue.

Summary

This gene is a member of the synaptotagmin gene family and encodes a protein similar to Other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

SYT11 Products (1)

mRNA Protein Name
NM_152280.5 NP_689493.3 synaptotagmin-11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
12925569 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagy IMP
IMP: Inferred from mutant phenotype
27278822 GOA
Cellular Component GO Annotation Evidence References Source
located in neuron projection IDA
IDA: Inferred from direct assay
12925569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYT11 Protein Structure

C2

C2: C2 domain (174 - 261)

C2

C2: C2 domain (309 - 396)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

synaptotagmin-11

  • synaptotagmin 12

SYT11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SYT11 Q9BT88 PRKN Homo sapiens O60260-5
Y2H Pooling
32814053
Intra
SYT11 Q9BT88 PRKN Homo sapiens O60260-5
Validated Y2H
32814053
Intra
SYT11 Q9BT88 PRKN Homo sapiens O60260-5
Y2H Array
32814053
Intra
SYT11 Q9BT88 SGTA Homo sapiens O43765
Validated Y2H
25416956
Intra
SYT11 Q9BT88 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
SYT11 Q9BT88 SGTA Homo sapiens O43765
Y2H Array
25416956
Intra
SYT11 Q9BT88 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
SYT11 Q9BT88 SGTA Homo sapiens O43765
Y2H
21516116
Intra
SYT11 Q9BT88 ATP13A2 Homo sapiens Q9NQ11
Anti Tag CoIP
22645275
Intra
SYT11 Q9BT88 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
SYT11 Q9BT88 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14108 SYT11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14109 SYT12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SYT11 MGD MGI:1859547
Bos taurus SYT11 VGNC VGNC:35537
Canis familiaris SYT11 VGNC VGNC:47042
Felis catus SYT11 VGNC VGNC:65893
Macaca mulatta SYT11 VGNC VGNC:78167
Rattus norvegicus SYT11 RGD RGD:62042
Others SYT11 NCBI