SYT11 - synaptotagmin 11 Gene

Homo sapiens

Also known as SYT12; sytXI

Gene ID: 23208 | Gene type: protein coding

About SYT11

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,859,567-155,885,199 (from NCBI)

This gene has 1 transcript (splice variant), 230 orthologues and 31 paralogues. Biased expression in brain (RPKM 160.9), adrenal (RPKM 11.8) and 1 other tissue.

Summary

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

SYT11 Products(1)

mRNA	Protein	Name
NM_152280.5	NP_689493.3	synaptotagmin-11

SYT11 Protein Structure

0
100
200
300
400
431 a.a.

Protein Preferred Names

Protein Names

synaptotagmin-11

synaptotagmin 12

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14108	SYT11 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SYT11	MGD	MGI:1859547
Bos taurus	SYT11	VGNC	VGNC:35537
Canis familiaris	SYT11	VGNC	VGNC:47042
Felis catus	SYT11	VGNC	VGNC:65893
Macaca mulatta	SYT11	VGNC	VGNC:78167
Rattus norvegicus	SYT11	RGD	RGD:62042

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