CORO2B - coronin 2B Gene

Also Known as CLIPINC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10391

Summary

Enables talin binding activity and vinculin binding activity. Acts upstream of or within several processes, including negative regulation of cell-substrate adhesion; regulation of actin Cytoskeleton organization; and regulation of establishment of protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]
Biased expression in brain (RPKM 22.9), ovary (RPKM 6.5) and 11 other tissues.

CORO2B Products (5)

mRNA Protein Name
NM_001190456.2 NP_001177385.1 coronin-2B isoform 2
NM_001190457.2 NP_001177386.1 coronin-2B isoform 2
NM_001324014.1 NP_001310943.1 coronin-2B isoform 2
NM_001324015.1 NP_001310944.1 coronin-2B isoform 2
NM_006091.5 NP_006082.3 coronin-2B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables talin binding IDA
IDA: Inferred from direct assay
29162887 GOA
enables vinculin binding IPI
IPI: Inferred from physical interaction
29162887 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
29162887 GOA
acts upstream of or within negative regulation of establishment of protein localization IDA
IDA: Inferred from direct assay
29162887 GOA
acts upstream of or within positive regulation of establishment of protein localization IDA
IDA: Inferred from direct assay
29162887 GOA
acts upstream of or within regulation of actin cytoskeleton organization IDA
IDA: Inferred from direct assay
29162887 GOA
acts upstream of or within regulation of cellular response to stress IDA
IDA: Inferred from direct assay
29162887 GOA
Cellular Component GO Annotation Evidence References Source
located in focal adhesion IDA
IDA: Inferred from direct assay
29162887 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORO2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CORO2B Q9UQ03 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
Intra
CORO2B Q9UQ03 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
CORO2B Q9UQ03 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra
CORO2B Q9UQ03 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03049 CORO1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03051 CORO2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown