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TSN - translin Gene

Also Known as C3PO; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7247

About TSN

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:121,755,651-121,767,853 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 26.5), brain (RPKM 20.8) and 25 other tissues.

Summary

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

TSN Products (2)

mRNA	Protein	Name
NM_001261401.2	NP_001248330.1	translin isoform 2
NM_004622.3	NP_004613.1	translin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21552258	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in siRNA processing	IDA IDA: Inferred from direct assay	21552258	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of endoribonuclease complex	IPI IPI: Inferred from physical interaction	21552258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSN Protein Structure

Translin

0
100
200
228 a.a.

Protein Preferred Names	Protein Names
translin	component 3 of promoter of RISC

TSN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TSN	Q15631	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	TSN	Q15631	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	TSN	Q15631	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	TSN	Q15631	TSNAX	Homo sapiens	Q99598	Ion Exchange Chrom	21552258
Intra	TSN	Q15631	TSN	Homo sapiens	Q15631	Y2H Array	21988832
Intra	TSN	Q15631	TSN	Homo sapiens	Q15631	Y2H Prey Pooling	32296183
Intra	TSN	Q15631	TSNAX	Homo sapiens	Q99598	Y2H Array	32296183
Intra	TSN	Q15631	TSNAX	Homo sapiens	Q99598	Pull Down	21552258
Intra	TSN	Q15631	TSNAX	Homo sapiens	Q99598	GMS	21552258
Intra	TSN	Q15631	TSNAX	Homo sapiens	Q99598	Anti Tag CoIP	33961781
Intra	TSN	Q15631	TSN	Homo sapiens	Q15631	Validated Y2H	32296183
Intra	TSN	Q15631	TSNAX	Homo sapiens	Q99598	Y2H Prey Pooling	32296183
Intra	TSN	Q15631	TSN	Homo sapiens	Q15631	Y2H Array	32296183
Intra	TSN	Q15631	TSNAX	Homo sapiens	Q99598	X-Ray Diffraction	21552258
Intra	TSN	Q15631	TSNAX	Homo sapiens	Q99598	Validated Y2H	32296183
Intra	TSN	Q15631	GIT2	Homo sapiens	Q14161	Y2H Array	21988832
Intra	TSN	Q15631	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	TSN	Q15631	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	TSN	Q15631	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	TSN	Q15631	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	TSN	Q15631	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	TSN	Q15631	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	TSN	Q15631	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Liposarcoma	Lipomatous Cancer
Dysgerminoma
Sotos Syndrome	Cerebral Gigantism SOTOS Chromosome 5q35 Deletion Syndrome Sotos Syndrome 1, Formerly Sotos1, Formerly Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development Sotos Sequence Sotos' Syndrome Sotos1 Sotos Syndrome 1
Chromosome 1p36 Deletion Syndrome	1p36 Deletion Syndrome Deletion 1p36 Monosomy 1p36 Subtelomeric 1p36 Deletion Monosomy 1p36 Syndrome Distal Monosomy 1p36 Del(1)(P36) Deletion 1pter Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13488	SND1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15154	TSN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18025	Tsn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24498	Tsn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TSN	VGNC	VGNC:47907
Bos taurus	TSN	VGNC	VGNC:36422
Macaca mulatta	TSN	VGNC	VGNC:78663
Felis catus	TSN	VGNC	VGNC:82547
Rattus norvegicus	TSN	RGD	RGD:621107
Mus musculus	TSN	MGD	MGI:109263
Others	TSN	NCBI