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NKD1 - NKD inhibitor of WNT signaling pathway 1 Gene

Also Known as Naked1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 85407

About NKD1

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,548,396-50,649,249 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 1 paralogue. Broad expression in lung (RPKM 3.1), brain (RPKM 2.1) and 20 other tissues.

Summary

In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

NKD1 Products (1)

mRNA	Protein	Name
NM_033119.5	NP_149110.1	protein naked cuticle homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15687260	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	27846906	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15687260	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	15687260	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	15687260	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein naked cuticle homolog 1	Dvl-binding protein

NKD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NKD1	Q969G9	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	NKD1	Q969G9	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	NKD1	Q969G9	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	NKD1	Q969G9	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
Intra	NKD1	Q969G9	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	NKD1	Q969G9	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	NKD1	Q969G9	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	NKD1	Q969G9	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	NKD1	Q969G9	KRTAP2-4	Homo sapiens	Q9BYR9	Validated Y2H	32296183
Intra	NKD1	Q969G9	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	NKD1	Q969G9	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	NKD1	Q969G9	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	NKD1	Q969G9	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	NKD1	Q969G9	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	NKD1	Q969G9	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	NKD1	Q969G9	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	NKD1	Q969G9	PPP2R3A	Homo sapiens	Q06190-1	Anti Bait CoIP	16567647
Intra	NKD1	Q969G9	PPP2R3A	Homo sapiens	Q06190-1	Anti Tag CoIP	16567647
Intra	NKD1	Q969G9	PPP2R3A	Homo sapiens	Q06190-2	Anti Tag CoIP	15687260
Intra	NKD1	Q969G9	PPP2R3A	Homo sapiens	Q06190-2	Anti Tag CoIP	16567647

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09317	NKD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20308	Nkd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26816	Nkd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NKD1	RGD	RGD:1308491
Macaca mulatta	NKD1	VGNC	VGNC:75198
Canis familiaris	NKD1	VGNC	VGNC:43828
Bos taurus	NKD1	VGNC	VGNC:32093
Mus musculus	NKD1	MGD	MGI:2135954
Others	NKD1	NCBI