CDYL2 - chromodomain Y like 2 Gene

Also Known as PCCP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 124359

About CDYL2

Cytogenetic location: 16q23.2 Genomic coordinates (GRCh38): 16:80,597,907-80,805,037 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues and 13 paralogues. Broad expression in testis (RPKM 6.1), placenta (RPKM 3.9) and 20 other tissues.

Summary

Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CDYL2 Products (1)

mRNA Protein Name
NM_152342.4 NP_689555.2 chromodomain Y-like protein 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17577209 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDYL2 Protein Structure

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (7 - 56)

ECH_1

ECH_1: Enoyl-CoA hydratase/isomerase (255 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 506 a.a.
Protein Preferred Names Protein Names

chromodomain Y-like protein 2

  • CDY-like 2

CDYL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDYL2 Q8N8U2 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra
CDYL2 Q8N8U2 PRMT5 Homo sapiens O14744
Anti Tag CoIP
23455924
Intra
CDYL2 Q8N8U2 PRMT5 Homo sapiens O14744
Y2H
23455924
Intra
CDYL2 Q8N8U2 ZBTB9 Homo sapiens Q96C00
Validated Y2H
32296183
Intra
CDYL2 Q8N8U2 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
CDYL2 Q8N8U2 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02434 CDYL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20879 Cdyl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27396 Cdyl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDYL2 RGD RGD:1309548
Mus musculus CDYL2 MGD MGI:1923046
Macaca mulatta CDYL2 VGNC VGNC:71076
Canis familiaris CDYL2 VGNC VGNC:53315
Felis catus CDYL2 VGNC VGNC:60724
Bos taurus CDYL2 VGNC VGNC:27160
Others CDYL2 NCBI