EIF3B - eukaryotic translation initiation factor 3 subunit B Gene
Also Known as PRT1; EIF3S9; EIF3-ETA; EIF3-P110; EIF3-P116
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 8662
About EIF3B
Cytogenetic location: 7p22.3
Genomic coordinates (GRCh38): 7:2,354,086-2,380,745 (from NCBI)
This gene has 12 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 39.5), bone marrow (RPKM 32.1) and 25 other tissues.
Summary
Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
EIF3B Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001037283.2 | NP_001032360.1 | eukaryotic translation initiation factor 3 subunit B isoform 1 |
| NM_001362791.2 | NP_001349720.1 | eukaryotic translation initiation factor 3 subunit B isoform 1 |
| NM_001362792.2 | NP_001349721.1 | eukaryotic translation initiation factor 3 subunit B isoform 2 |
| NM_001362793.2 | NP_001349722.1 | eukaryotic translation initiation factor 3 subunit B isoform 2 |
| NM_003751.4 | NP_003742.2 | eukaryotic translation initiation factor 3 subunit B isoform 1 |
EIF3B Protein Structure
RRM_1
RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (207 - 257)
eIF2A
eIF2A: Eukaryotic translation initiation factor eIF2A (507 - 701)
- 0
- 200
- 400
- 600
- 814 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
eukaryotic translation initiation factor 3 subunit B |
|
EIF3B Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
EIF3B | P55884 | RPS6KB1 | Homo sapiens | P23443 | 18423201 | |
|
Intra
|
EIF3B | P55884 | RPS6KB1 | Homo sapiens | P23443 | 21986499 | |
|
Intra
|
EIF3B | P55884 | EIF3E | Homo sapiens | P60228 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3E | Homo sapiens | P60228 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3E | Homo sapiens | P60228 | 35271311 | |
|
Intra
|
EIF3B | P55884 | EIF3E | Homo sapiens | P60228 | 18628297 | |
|
Intra
|
EIF3B | P55884 | DDX3X | Homo sapiens | O00571 | 18628297 | |
|
Intra
|
EIF3B | P55884 | EIF3M | Homo sapiens | Q7L2H7 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3M | Homo sapiens | Q7L2H7 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3M | Homo sapiens | Q7L2H7 | 35271311 | |
|
Intra
|
EIF3B | P55884 | EIF3I | Homo sapiens | Q13347 | 14688252 | |
|
Intra
|
EIF3B | P55884 | EIF3I | Homo sapiens | Q13347 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3I | Homo sapiens | Q13347 | 18628297 | |
|
Intra
|
EIF3B | P55884 | EIF3I | Homo sapiens | Q13347 | 35271311 | |
|
Intra
|
EIF3B | P55884 | EIF3K | Homo sapiens | Q9UBQ5 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3K | Homo sapiens | Q9UBQ5 | 35271311 | |
|
Intra
|
EIF3B | P55884 | EIF3K | Homo sapiens | Q9UBQ5 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3K | Homo sapiens | Q9UBQ5 | 18628297 | |
|
Intra
|
EIF3B | P55884 | EIF3A | Homo sapiens | Q14152 | 19245811 | |
|
Intra
|
EIF3B | P55884 | EIF3A | Homo sapiens | Q14152 | 18628297 | |
|
Intra
|
EIF3B | P55884 | EIF3A | Homo sapiens | Q14152 | 35271311 | |
|
Intra
|
EIF3B | P55884 | EIF3A | Homo sapiens | Q14152 | 14688252 | |
|
Intra
|
EIF3B | P55884 | EIF3G | Homo sapiens | O75821 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3G | Homo sapiens | O75821 | 35271311 | |
|
Intra
|
EIF3B | P55884 | EIF3G | Homo sapiens | O75821 | 14688252 | |
|
Intra
|
EIF3B | P55884 | EIF3G | Homo sapiens | O75821 | 30021884 | |
|
Intra
|
EIF3B | P55884 | EIF3G | Homo sapiens | O75821 | 18628297 | |
|
Intra
|
EIF3B | P55884 | EIF3J | Homo sapiens | O75822 | 14688252 | |
|
Intra
|
EIF3B | P55884 | EIF3J | Homo sapiens | O75822 | 18628297 | |
|
Intra
|
EIF3B | P55884 | EIF3J | Homo sapiens | O75822 | 35271311 | |
|
Intra
|
EIF3B | P55884 | EIF3L | Homo sapiens | Q9Y262 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3L | Homo sapiens | Q9Y262 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3L | Homo sapiens | Q9Y262 | 35271311 | |
|
Intra
|
EIF3B | P55884 | EIF3H | Homo sapiens | O15372 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3H | Homo sapiens | O15372 | 18628297 | |
|
Intra
|
EIF3B | P55884 | EIF3H | Homo sapiens | O15372 | 35271311 | |
|
Intra
|
EIF3B | P55884 | EIF3H | Homo sapiens | O15372 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3F | Homo sapiens | O00303 | 18628297 | |
|
Intra
|
EIF3B | P55884 | EIF3F | Homo sapiens | O00303 | 35271311 | |
|
Intra
|
EIF3B | P55884 | EIF3F | Homo sapiens | O00303 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3F | Homo sapiens | O00303 | 18599441 | |
|
Intra
|
EIF3B | P55884 | EIF3F | Homo sapiens | O00303 | 19245811 | |
|
Intra
|
EIF3B | P55884 | EIF4G1 | Homo sapiens | Q04637 | 23023399 | |
|
Intra
|
EIF3B | P55884 | EIF4G1 | Homo sapiens | Q04637 | 35271311 | |
|
Cross
|
EIF3B | P55884 | UL54 | Human herpesvirus 1 | Q9J0X9 | 15567442 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
EIF3B Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83000 | eIF3B Antibody (YA2745) | WB, IHC-P | Human |
| HY-P83000A | eIF3B Antibody (YA2745)(PBS only) | WB, IHC-P | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Craniotubular Dysplasia, Ikegawa Type |
|
|
| Mouth Disease |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS04258 | EIF3B Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | EIF3B | VGNC | VGNC:72193 |
| Bos taurus | EIF3B | VGNC | VGNC:28393 |
| Rattus norvegicus | EIF3B | RGD | RGD:1309018 |
| Canis familiaris | EIF3B | VGNC | VGNC:40269 |
| Felis catus | EIF3B | VGNC | VGNC:61781 |
| Mus musculus | EIF3B | MGD | MGI:106478 |
| Others | EIF3B | NCBI |
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