EIF3J - eukaryotic translation initiation factor 3 subunit J Gene

Also Known as EIF3S1; eIF3-p35; eIF3-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8669

About EIF3J

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:44,537,147-44,562,803 (from NCBI)

This gene has 7 transcripts (splice variants) and 248 orthologues. Ubiquitous expression in appendix (RPKM 31.0), brain (RPKM 29.6) and 25 other tissues.

Summary

This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

EIF3J Products (3)

mRNA Protein Name
NM_001284335.2 NP_001271264.1 eukaryotic translation initiation factor 3 subunit J isoform 2
NM_001284336.2 NP_001271265.1 eukaryotic translation initiation factor 3 subunit J isoform 3
NM_003758.4 NP_003749.2 eukaryotic translation initiation factor 3 subunit J isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14688252 GOA
Cellular Component GO Annotation Evidence References Source
part of eukaryotic translation initiation factor 3 complex IDA
IDA: Inferred from direct assay
17322308 GOA
part of eukaryotic translation initiation factor 3 complex IPI
IPI: Inferred from physical interaction
17322308 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3J Protein Structure

eIF3_subunit

eIF3_subunit: Translation initiation factor eIF3 subunit (12 - 258)

  • 0
  • 100
  • 200
  • 258 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 3 subunit J

  • eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD)

EIF3J Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF3J O75822 ABCE1 Homo sapiens P61221
Validated Y2H
32296183
Intra
EIF3J O75822 EIF3A Homo sapiens Q14152
Pull Down
23623729
Intra
EIF3J O75822 EIF3B Homo sapiens P55884
Anti Tag CoIP
14688252
Intra
EIF3J O75822 EIF4G1 Homo sapiens Q04637
Pull Down
16932749
Intra
EIF3J O75822 EIF4G1 Homo sapiens Q04637
Anti Tag CoIP
16932749
Cross: Cross-species interaction Intra: Intraspecies interaction

EIF3J Antibodies

Cat. No. Product Name Application Reactivity
HY-P86860 EIF3S1/EIF3J Antibody (YA6553) WB, ICC/IF, IHC-P, FC Human, Rat, Monkey

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04266 EIF3J Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EIF3J VGNC VGNC:80979
Mus musculus EIF3J MGD MGI:1925905
Canis familiaris EIF3J VGNC VGNC:40276
Bos taurus EIF3J VGNC VGNC:28400
Macaca mulatta EIF3J VGNC VGNC:72188
Rattus norvegicus EIF3J RGD RGD:1593338
Others EIF3J NCBI