EIF3I - eukaryotic translation initiation factor 3 subunit I Gene

Also Known as TRIP1; EIF3S2; TRIP-1; PRO2242; eIF3-p36; eIF3-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8668

About EIF3I

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:32,222,407-32,236,170 (from NCBI)

This gene has 44 transcripts (splice variants) and 168 orthologues. Ubiquitous expression in thyroid (RPKM 51.3), ovary (RPKM 48.1) and 25 other tissues.

Summary

Contributes to translation initiation factor activity. Involved in translational initiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3I Products (2)

mRNA	Protein	Name
NM_001394168.1	NP_001381097.1	eukaryotic translation initiation factor 3 subunit I isoform 2
NM_003757.4	NP_003748.1	eukaryotic translation initiation factor 3 subunit I isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14688252	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	25849773	GOA
enables translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3I Protein Structure

WD40

0
100
200
300
325 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 3 subunit I	TGF-beta receptor-interacting protein 1

EIF3I Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF3I	Q13347	CLEC4G	Homo sapiens	Q6UXB4	Anti Tag CoIP	18624398
Intra	EIF3I	Q13347	CLEC4G	Homo sapiens	Q6UXB4	Confocal	18624398
Intra	EIF3I	Q13347	CLEC4G	Homo sapiens	Q6UXB4	Y2H	18624398
Intra	EIF3I	Q13347	EIF3G	Homo sapiens	O75821	Anti Tag CoIP	33961781
Intra	EIF3I	Q13347	EIF3G	Homo sapiens	O75821	Anti Tag CoIP	35271311
Intra	EIF3I	Q13347	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	35271311
Intra	EIF3I	Q13347	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Stomatitis
Clonorchiasis	Oriental Liver Fluke Disease Clonorchis Liver Infection Clonorchiosis Chinese Liver Fluke Disease Hepatic Distomiasis Due To Clonorchis Sinensis Infection Due To Clonorchis Sinensis Hepatic Distomiasis Hepatic Distomatosis Chinese Liver Fluke Disorder Oriental Liver Fluke Disorder Clonorchis Infestation Chinese Liver Fluke Infestation Liver Fluke Disease Due To Clonorchis Sinensis Oriental Liver Fluke Infestation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04265	EIF3I Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-149289	DNMT-IN-3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EIF3I	MGD	MGI:1860763
Felis catus	EIF3I	VGNC	VGNC:61784
Canis familiaris	EIF3I	VGNC	VGNC:40275
Macaca mulatta	EIF3I	VGNC	VGNC:99897
Rattus norvegicus	EIF3I	RGD	RGD:1584560
Bos taurus	EIF3I	VGNC	VGNC:28399
Others	EIF3I	NCBI