EIF3C - eukaryotic translation initiation factor 3 subunit C Gene

Homo sapiens

Also known as EIF3CL; EIF3S8; eIF3-p110

Gene ID: 8663 | Gene type: protein coding

About EIF3C

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,688,558-28,735,730 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 96.4), thyroid (RPKM 93.0) and 25 other tissues.

Summary

Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3C Products(5)

mRNA	Protein	Name
NM_001037808.2	NP_001032897.1	eukaryotic translation initiation factor 3 subunit C isoform a
NM_001199142.1	NP_001186071.1	eukaryotic translation initiation factor 3 subunit C isoform a
NM_001267574.2	NP_001254503.1	eukaryotic translation initiation factor 3 subunit C isoform a
NM_001286478.1	NP_001273407.1	eukaryotic translation initiation factor 3 subunit C isoform b
NM_003752.5	NP_003743.1	eukaryotic translation initiation factor 3 subunit C isoform a

EIF3C Protein Structure

eIF-3c_N

PCI

0
200
400
600
800
913 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit C

cell migration-inducing protein 17

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04259	EIF3C Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EIF3C	MGD	MGI:1926966
Rattus norvegicus	EIF3C	RGD	RGD:1308871

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