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ZFYVE21 - zinc finger FYVE-type containing 21 Gene

Also Known as ZF21; HCVP7TP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79038

About ZFYVE21

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,715,810-103,733,664 (from NCBI)

This gene has 12 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in fat (RPKM 36.0), endometrium (RPKM 31.2) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Predicted to be located in endosome and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

ZFYVE21 Products (2)

mRNA	Protein	Name
NM_001198953.2	NP_001185882.1	zinc finger FYVE domain-containing protein 21 isoform 1
NM_024071.4	NP_076976.1	zinc finger FYVE domain-containing protein 21 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE21 Protein Structure

FYVE

0
100
200
234 a.a.

Protein Preferred Names	Protein Names
zinc finger FYVE domain-containing protein 21	FYVE domain containing 21

ZFYVE21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZFYVE21	Q9BQ24	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	KRTAP10-5	Homo sapiens	P60370	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	ZFYVE21	Q9BQ24	RTN4	Homo sapiens	Q9NQC3-2	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	RTN4	Homo sapiens	Q9NQC3-2	Y2H Prey Pooling	25416956
Intra	ZFYVE21	Q9BQ24	KRT38	Homo sapiens	O76015	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	KRT38	Homo sapiens	O76015	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	PDE4DIP	Homo sapiens	Q5VU43	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	PDE4DIP	Homo sapiens	Q5VU43	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	SMIM5	Homo sapiens	Q71RC9	Y2H Array	32296183
Intra	ZFYVE21	Q9BQ24	SMIM5	Homo sapiens	Q71RC9	Y2H Prey Pooling	32296183
Intra	ZFYVE21	Q9BQ24	REEP6	Homo sapiens	Q96HR9-2	Y2H Array	32296183
Intra	ZFYVE21	Q9BQ24	REEP6	Homo sapiens	Q96HR9-2	Y2H Prey Pooling	32296183
Intra	ZFYVE21	Q9BQ24	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Array	32296183
Intra	ZFYVE21	Q9BQ24	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Prey Pooling	32296183
Intra	ZFYVE21	Q9BQ24	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
Intra	ZFYVE21	Q9BQ24	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
Intra	ZFYVE21	Q9BQ24	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	ZFYVE21	Q9BQ24	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	ZFYVE21	Q9BQ24	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	ZFYVE21	Q9BQ24	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	ZFYVE21	Q9BQ24	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	RABAC1	Homo sapiens	Q9UI14	Y2H Prey Pooling	32296183
Intra	ZFYVE21	Q9BQ24	RABAC1	Homo sapiens	Q9UI14	Validated Y2H	32296183
Intra	ZFYVE21	Q9BQ24	RABAC1	Homo sapiens	Q9UI14	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	RABAC1	Homo sapiens	Q9UI14	Y2H Array	32296183
Intra	ZFYVE21	Q9BQ24	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	25416956
Intra	ZFYVE21	Q9BQ24	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
Intra	ZFYVE21	Q9BQ24	ARL6IP1	Homo sapiens	Q15041	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
Intra	ZFYVE21	Q9BQ24	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	RTN4	Homo sapiens	Q9NQC3	Y2H Prey Pooling	25416956
Intra	ZFYVE21	Q9BQ24	RTN4	Homo sapiens	Q9NQC3	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	AGTRAP	Homo sapiens	Q6RW13	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956
Intra	ZFYVE21	Q9BQ24	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	REEP6	Homo sapiens	Q96HR9	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	ZFYVE21	Q9BQ24	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	ZFYVE21	Q9BQ24	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	ZFYVE21	Q9BQ24	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	ZFYVE21	Q9BQ24	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	ZFYVE21	Q9BQ24	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16058	ZFYVE21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZFYVE21	MGD	MGI:1915770
Felis catus	ZFYVE21	VGNC	VGNC:67240
Rattus norvegicus	ZFYVE21	RGD	RGD:1311036
Canis familiaris	ZFYVE21	VGNC	VGNC:48625
Bos taurus	ZFYVE21	VGNC	VGNC:55897
Macaca mulatta	ZFYVE21	VGNC	VGNC:79282
Others	ZFYVE21	NCBI