RTN4 - reticulon 4 Gene

Also Known as ASY; NSP; NOGO; RTN-X; NSP-CL; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57142

About RTN4

Cytogenetic location: 2p16.1 Genomic coordinates (GRCh38): 2:54,972,189-55,137,831 (from NCBI)

This gene has 14 transcripts (splice variants), 221 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 122.1), brain (RPKM 104.7) and 24 other tissues.

Summary

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

RTN4 Products (11)

mRNA	Protein	Name
NM_001321859.2	NP_001308788.1	reticulon-4 isoform E
NM_001321860.1	NP_001308789.1	reticulon-4 isoform E
NM_001321861.2	NP_001308790.1	reticulon-4 isoform E
NM_001321862.2	NP_001308791.1	reticulon-4 isoform E
NM_001321863.2	NP_001308792.1	reticulon-4 isoform E
NM_001321904.2	NP_001308833.1	reticulon-4 isoform E
NM_007008.3	NP_008939.1	reticulon-4 isoform C
NM_020532.5	NP_065393.1	reticulon-4 isoform A
NM_153828.3	NP_722550.1	reticulon-4 isoform B
NM_207520.2	NP_997403.1	reticulon-4 isoform D
NM_207521.2	NP_997404.1	reticulon-4 isoform E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cadherin binding	IPI IPI: Inferred from physical interaction	21183689	GOA
enables metal ion binding	EXP EXP: Inferred from Experiment	15317586	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11126360	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	27786289	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	27353365	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell adhesion involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	15034570	GOA
involved in endoplasmic reticulum organization	IDA IDA: Inferred from direct assay	27786289	GOA
involved in endoplasmic reticulum tubular network formation	IDA IDA: Inferred from direct assay	24262037	GOA
involved in endoplasmic reticulum tubular network membrane organization	IMP IMP: Inferred from mutant phenotype	27619977	GOA
involved in endoplasmic reticulum tubular network organization	IMP IMP: Inferred from mutant phenotype	18779370	GOA
involved in negative regulation of amyloid-beta formation	IDA IDA: Inferred from direct assay	15286784	GOA
involved in negative regulation of axon extension	IDA IDA: Inferred from direct assay	10667797	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	20463223	GOA
involved in nuclear pore complex assembly	IMP IMP: Inferred from mutant phenotype	26906412	GOA
involved in positive regulation of ERBB3 signaling pathway	IMP IMP: Inferred from mutant phenotype	27353365	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	27353365	GOA
involved in positive regulation of mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	27353365	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	27353365	GOA
involved in positive regulation of protein localization to endoplasmic reticulum	IDA IDA: Inferred from direct assay	27353365	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	27353365	GOA
acts upstream of or within regulation of cell migration	IDA IDA: Inferred from direct assay	15034570	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell junction	IDA IDA: Inferred from direct assay	21183689	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10667797	GOA
located in endoplasmic reticulum tubular network	IDA IDA: Inferred from direct assay	27353365	GOA
located in endoplasmic reticulum tubular network membrane	IDA IDA: Inferred from direct assay	27619977	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	11126360	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15034570	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTN4 Protein Structure

Reticulon

0
200
400
600
800
1000
1192 a.a.

Protein Preferred Names	Protein Names
reticulon-4	Human NogoA

RTN4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RTN4	Q9NQC3	SYT16	Homo sapiens	Q17RD7	Y2H Array	29892012
Intra	RTN4	Q9NQC3	SYT16	Homo sapiens	Q17RD7	Y2H Array	31515488
Intra	RTN4	Q9NQC3	SYT16	Homo sapiens	Q17RD7	Y2H Prey Pooling	25416956
Intra	RTN4	Q9NQC3	SYT16	Homo sapiens	Q17RD7	Validated Y2H	25416956
Intra	RTN4	Q9NQC3	RTN2	Homo sapiens	O75298	Anti Tag CoIP	35271311
Intra	RTN4	Q9NQC3	RTN2	Homo sapiens	O75298	Anti Tag CoIP	33961781
Intra	RTN4	Q9NQC3	SNX1	Homo sapiens	Q13596	Y2H Prey Pooling	25416956
Intra	RTN4	Q9NQC3	ZFYVE21	Homo sapiens	Q9BQ24	Y2H Array	25416956
Intra	RTN4	Q9NQC3	ARL6IP1	Homo sapiens	Q15041	Anti Tag CoIP	33961781
Intra	RTN4	Q9NQC3	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	25416956
Intra	RTN4	Q9NQC3	SNX15	Homo sapiens	Q9NRS6	Validated Y2H	25416956
Intra	RTN4	Q9NQC3	SNX15	Homo sapiens	Q9NRS6	Y2H Array	25416956
Intra	RTN4	Q9NQC3	CERT1	Homo sapiens	Q9Y5P4	Y2H Array	29892012
Intra	RTN4	Q9NQC3	CERT1	Homo sapiens	Q9Y5P4	Y2H Array	31515488
Intra	RTN4	Q9NQC3	RTN3	Homo sapiens	O95197	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

RTN4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81675	Nogo Antibody (YA1420)	WB, IHC-P, ICC/IF, FC, IP	Human

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Anosognosia
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Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Cholestasis, Intrahepatic, Of Pregnancy 3	ICP3 Cholestasis, Intrahepatic, Of Pregnancy, 3 Intrahepatic Cholestasis Of Pregnancy 3 Pregnancy Related Cholestasis 3 Cholestasis Of Pregnancy, Intrahepatic 3 Cholestasis, Intrahepatic, Of Pregnancy, Type 3
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Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12332	RTN4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12333	RTN4IP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12334	RTN4R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12335	RTN4RL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18682	Rtn4r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18788	Rtn4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20640	Rtn4rl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25168	Rtn4r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25277	Rtn4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27150	Rtn4rl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RTN4	VGNC	VGNC:106215
Felis catus	RTN4	VGNC	VGNC:81215
Bos taurus	RTN4	VGNC	VGNC:106907
Mus musculus	RTN4	MGD	MGI:1915835
Rattus norvegicus	RTN4	RGD	RGD:620989
Canis familiaris	RTN4	VGNC	VGNC:54541
Others	RTN4	NCBI