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SNX15 - sorting nexin 15 Gene

Also Known as HSAF001435

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29907

About SNX15

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,027,439-65,040,572 (from NCBI)

This gene has 7 transcripts (splice variants), 182 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 9.4), kidney (RPKM 8.6) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of Insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of Furin, the endoprotease responsible for cleavage of Insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

SNX15 Products (2)

mRNA	Protein	Name
NM_013306.5	NP_037438.2	sorting nexin-15 isoform A
NM_147777.4	NP_680086.2	sorting nexin-15 isoform B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX15 Protein Structure

MIT

0
100
200
300
342 a.a.

Protein Preferred Names	Protein Names
sorting nexin-15	clone iota unknown protein

SNX15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNX15	Q9NRS6	REEP6	Homo sapiens	Q96HR9-2	Y2H Array	32296183
Intra	SNX15	Q9NRS6	REEP6	Homo sapiens	Q96HR9-2	Y2H Prey Pooling	32296183
Intra	SNX15	Q9NRS6	RABAC1	Homo sapiens	Q9UI14	Y2H Prey Pooling	25416956
Intra	SNX15	Q9NRS6	RABAC1	Homo sapiens	Q9UI14	Y2H Array	25416956
Intra	SNX15	Q9NRS6	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	25416956
Intra	SNX15	Q9NRS6	ARL6IP1	Homo sapiens	Q15041	Y2H Array	25416956
Intra	SNX15	Q9NRS6	RTN4	Homo sapiens	Q9NQC3	Y2H Prey Pooling	25416956
Intra	SNX15	Q9NRS6	RTN4	Homo sapiens	Q9NQC3	Y2H	21516116
Intra	SNX15	Q9NRS6	NT5C2	Homo sapiens	P49902	Anti Tag CoIP	33961781
Intra	SNX15	Q9NRS6	NT5C2	Homo sapiens	P49902	Anti Tag CoIP	28514442
Intra	SNX15	Q9NRS6	REEP6	Homo sapiens	Q96HR9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13528	SNX15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNX15	MGD	MGI:1916274
Canis familiaris	SNX15	VGNC	VGNC:46624
Macaca mulatta	SNX15	VGNC	VGNC:107646
Rattus norvegicus	SNX15	RGD	RGD:1305803
Bos taurus	SNX15	VGNC	VGNC:35095
Felis catus	SNX15	VGNC	VGNC:81935
Others	SNX15	NCBI