LINGO1 - leucine rich repeat and Ig domain containing 1 Gene

Also Known as LERN1; MRT64; LRRN6A; UNQ201

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84894

About LINGO1

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:77,613,027-77,820,900 (from NCBI)

This gene has 14 transcripts (splice variants), 261 orthologues, 25 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 24.2), placenta (RPKM 1.9) and 3 other tissues.

Summary

Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. [provided by Alliance of Genome Resources, Apr 2022]

LINGO1 Products (12)

mRNA	Protein	Name
NM_001301186.2	NP_001288115.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301187.2	NP_001288116.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301189.2	NP_001288118.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301191.2	NP_001288120.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301192.2	NP_001288121.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301194.2	NP_001288123.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301195.2	NP_001288124.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301197.2	NP_001288126.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301198.2	NP_001288127.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301199.2	NP_001288128.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301200.2	NP_001288129.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_032808.7	NP_116197.4	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14966521	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LINGO1 Protein Structure

LRR_8

LRR_1

LRR_8

I-set

0
100
200
300
400
500
620 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1	leucine rich repeat neuronal 6A

LINGO1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LINGO1	Q96FE5	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	LINGO1	Q96FE5	NTM	Homo sapiens	Q9P121-3	Validated Y2H	32296183
Intra	LINGO1	Q96FE5	NGFR	Homo sapiens	P08138	Anti Tag CoIP	20659559
Intra	LINGO1	Q96FE5	MACO1	Homo sapiens	Q8N5G2	Y2H Array	32296183
Intra	LINGO1	Q96FE5	EGFR	Homo sapiens	P00533	Anti Bait CoIP	17726113
Intra	LINGO1	Q96FE5	APP	Homo sapiens	P05067-4	Anti Bait CoIP	22133804
Intra	LINGO1	Q96FE5	APP	Homo sapiens	P05067-4	Anti Tag CoIP	22133804
Intra	LINGO1	Q96FE5	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	LINGO1	Q96FE5	SPAG5	Homo sapiens	Q96R06	Y2H Prey Pooling	25416956
Intra	LINGO1	Q96FE5	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	LINGO1	Q96FE5	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	LINGO1	Q96FE5	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	LINGO1	Q96FE5	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	LINGO1	Q96FE5	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Cross	LINGO1	Q96FE5	Rtn4r	Rattus norvegicus	Q99M75	ELISA	14966521

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Recessive 64	MRT64 Mental Retardation, Autosomal Recessive 64 Autosomal Recessive Intellectual Developmental Disorder 64 Mental Retardation, Autosomal Recessive, Type 64
Essential Tremor	Benign Essential Tremor Familial Tremor Hereditary Essential Tremor Essential Hereditary Tremor Shaky Hand Syndrome Benign Essential Tremor Syndrome Tremor Hereditary Essential Essential Tremor, Susceptibility To Tremor, Hereditary Essential
Tremor, Hereditary Essential, 1	ETM1 Fet1 Essential Tremor 1 Tremor, Familial Essential, 1 Essential Tremor, Hereditary, 1 Hereditary Essential Tremor 1 Tremor Hereditary Essential, 1 Tremor Familial Essential, 1 Tremor, Hereditary Essential 1 Tremor, Essential Hereditary, Type 1
Syndromic Intellectual Disability
Developmental And Epileptic Encephalopathy 24	DEE24 Epileptic Encephalopathy, Early Infantile, 24 Eiee24 Developmental And Epileptic Encephalopathy, 24 Early Infantile Epileptic Encephalopathy 24 Encephalopathy, Epileptic, Early Infantile, Type 24
Leber Optic Atrophy And Dystonia	LDYT Marsden Syndrome Leber Hereditary Optic Neuropathy With Dystonia Leber Hereditary Optic Neuropathy And Dystonia Familial Dystonia With Visual Failure And Striatal Lucencies Dystonia, Familial, With Visual Failure And Striatal Lucencies Leber Optic Atrophy With Dystonia Dystonia Familial, With Visual Failure And Striatal Lucencies Lhon And Dystonia Leber'S Hereditary Optic Neuropathy With Dystonia
Primary Progressive Multiple Sclerosis	Ppms Primary-Progressive Ms Multiple Sclerosis, Primary Progressive
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid
Pelizaeus-Merzbacher Disease	PMD HLD1 Pelizaeus-Merzbacher Brain Sclerosis Leukodystrophy, Hypomyelinating, 1 Diffuse Familial Brain Sclerosis Pelizaeus Merzbacher Brain Sclerosis Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type Cockayne-Pelizaeus-Merzbacher Disease Hypomyelinating Leukodystrophy 1 Leukodystrophy, Sudanophilic Pelizaeus Merzbacher Disease Hypomyelinating Leukodystrophy, 1 Sudanophilic Leukodystrophy Pelizaeus-Merzbacher Disease, Connatal Form Connatal Pmd Pelizaeus-Merzbacher Disease Type Ii Severe Pmd Null Syndrome Plp1 Null Syndrome Pelizaeus-Merzbacher Disease, Null Syndrome Brain Sclerosis Diffuse Familial Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type Leukodystrophy Hypomyelinating 1 Diffuse Cerebral Sclerosis Of Schilder
Optic Nerve Disease	Optic Neuropathy Disorder Of The Second Nerve Optic Nerve Disorder Optic Nerve Abnormality Of The Optic Nerve Optic Nerve Disorders Neuropathy, Optic Disorder Of The Optic Nerve
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Hypomyelinating Leukodystrophy	Hld Leukodystrophy, Hypomyelinating
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99780	Opicinumab	Antagonist	99.64%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07680	LINGO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LINGO1	VGNC	VGNC:74094
Bos taurus	LINGO1	VGNC	VGNC:30899
Canis familiaris	LINGO1	VGNC	VGNC:42688
Felis catus	LINGO1	VGNC	VGNC:63236
Mus musculus	LINGO1	MGD	MGI:1915522
Rattus norvegicus	LINGO1	RGD	RGD:1308668
Others	LINGO1	NCBI