2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Opicinumab

Opicinumab  (Synonyms: BIIB033)

Cat. No.: HY-P99780 Purity: 99.5%
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Opicinumab (BIIB033) is a human IgG1 monoclonal antibody targeting LINGO-1. Opicinumab binds LINGO-1 to block its negative regulatory signaling, suppress axonal degeneration, enhance axonal regeneration, promote remyelination, and exert neuroprotective effects. Opicinumab maintains axonal protective effects during co-administration with methylprednisolone. Opicinumab can be used for the research of multiple sclerosis, acute optic neuritis, and optic neuritis..

For research use only. We do not sell to patients.

CAS No. : 1422268-07-2

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Description

Opicinumab (BIIB033) is a human IgG1 monoclonal antibody targeting LINGO-1. Opicinumab binds LINGO-1 to block its negative regulatory signaling, suppress axonal degeneration, enhance axonal regeneration, promote remyelination, and exert neuroprotective effects. Opicinumab maintains axonal protective effects during co-administration with methylprednisolone. Opicinumab can be used for the research of multiple sclerosis, acute optic neuritis, and optic neuritis.[1][2][3].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target[1]

LINGO-1

 

In Vivo

Opicinumab (0.1-100 mg/kg; systemic) drives dose-dependent spinal cord remyelination in lysolecithin-induced demyelinating rats, with an EC50 of 30 ng/mL and EC90 of 100 ng/mL in cerebrospinal fluid[1].
Opicinumab (BIIB033) (6 mg/kg; i.p.; once weekly; 3 doses) significantly reduces optic nerve axonal loss in Brown Norway rats with MOG-induced experimental autoimmune encephalomyelitis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Brown Norway rats (8-10-week-old female; MOG-induced experimental autoimmune encephalomyelitis)[3]
Dosage: 6 mg/kg
Administration: i.p.; once weekly; 3 doses
Result: Exhibited a five-fold higher number of βIII tubulin-positive axons compared to control when administered alone with vehicle.
Exhibited an eight-fold higher number of βIII tubulin-positive axons compared to control when administered in combination with Methylprednisolone.
Clinical Trial
Gene ID

84894  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.2 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Opicinumab]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 99.5%

SDS (251 KB)

COA (232 KB) SDS-PAGE (311 KB) SEC-HPLC (104 KB)

Inhibitory Antibodies User Guide (603 KB)
References
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Opicinumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Opicinumab1422268-07-2BIIB033BIIB 033BIIB-033Transmembrane Glycoproteinaxonal degenerationaxonal regenerationcentral nervous systemlysolecithin-induced demyelinating ratsmultiple sclerosisacute optic neuritisLINGO-1remyelinationoptic neuritisBrown Norway ratsInhibitorinhibitorinhibit

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