Rtn4r - reticulon 4 receptor Gene

Also Known as NgR; NgR1; Nogor

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 113912

Summary

Enables signaling receptor activity. Involved in cell surface receptor signaling pathway and negative regulation of neuron projection development. Located in cell surface and membrane raft. Is active in glutamatergic synapse and presynapse. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human RTN4R (reticulon 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Rtn4r Products (1)

mRNA Protein Name
NM_053613.2 NP_446065.2 reticulon-4 receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14966521 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
23613963 RGD
enables signaling receptor activity IMP
IMP: Inferred from mutant phenotype
15673660 RGD
Biological Process GO Annotation Evidence References Source
involved in cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15673660 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
15673660 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15673660 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24966370 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
15673660 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
24966370 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

reticulon-4 receptor

  • Nogo66 receptor

  • nogo receptor

  • nogo-66 receptor

Rtn4r Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Rtn4r Q99M75 LINGO1 Homo sapiens Q96FE5
ELISA
14966521
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12334 RTN4R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18682 Rtn4r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25168 Rtn4r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rtn4r NCBI NCBI:65078