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MACO1 - macoilin 1 Gene

Also Known as TMEM57; MACOILIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55219

About MACO1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:25,430,897-25,500,209 (from NCBI)

This gene has 4 transcripts (splice variants) and 286 orthologues. Ubiquitous expression in testis (RPKM 13.0), bone marrow (RPKM 10.8) and 25 other tissues.

Summary

Predicted to enable actin filament binding activity and microtubule binding activity. Involved in neuronal signal transduction. Located in rough endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

MACO1 Products (2)

mRNA	Protein	Name
NM_001282564.2	NP_001269493.1	macoilin isoform b
NM_018202.6	NP_060672.2	macoilin isoform a

MACO1 Protein Structure

Macoilin

0
200
400
600
664 a.a.

Protein Preferred Names	Protein Names
macoilin	transmembrane protein 57

MACO1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MACO1	Q8N5G2	LCE3E	Homo sapiens	Q5T5B0	Y2H Array	32296183
Intra	MACO1	Q8N5G2	LCE3E	Homo sapiens	Q5T5B0	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	TMEM190	Homo sapiens	Q8WZ59	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	TMEM190	Homo sapiens	Q8WZ59	Validated Y2H	32296183
Intra	MACO1	Q8N5G2	TMEM190	Homo sapiens	Q8WZ59	Y2H Array	32296183
Intra	MACO1	Q8N5G2	LCE1D	Homo sapiens	Q5T752	Y2H Array	32296183
Intra	MACO1	Q8N5G2	LCE1D	Homo sapiens	Q5T752	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	LCE1E	Homo sapiens	Q5T753	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	LCE1E	Homo sapiens	Q5T753	Y2H Array	32296183
Intra	MACO1	Q8N5G2	LCE1F	Homo sapiens	Q5T754	Y2H Array	32296183
Intra	MACO1	Q8N5G2	LCE1F	Homo sapiens	Q5T754	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	KRTAP5-2	Homo sapiens	Q701N4	Y2H Array	32296183
Intra	MACO1	Q8N5G2	KRTAP5-2	Homo sapiens	Q701N4	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
Intra	MACO1	Q8N5G2	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	MACO1	Q8N5G2	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	MACO1	Q8N5G2	NR4A3	Homo sapiens	Q92570	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	NR4A3	Homo sapiens	Q92570	Validated Y2H	32296183
Intra	MACO1	Q8N5G2	NR4A3	Homo sapiens	Q92570	Y2H Array	32296183
Intra	MACO1	Q8N5G2	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	MACO1	Q8N5G2	POTEB3	Homo sapiens	A0JP26	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	POTEB3	Homo sapiens	A0JP26	Y2H Array	32296183
Intra	MACO1	Q8N5G2	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	MACO1	Q8N5G2	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	MACO1	Q8N5G2	CCN3	Homo sapiens	P48745	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	CCN3	Homo sapiens	P48745	Y2H Array	32296183
Intra	MACO1	Q8N5G2	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	MACO1	Q8N5G2	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	MACO1	Q8N5G2	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	CRCT1	Homo sapiens	Q9UGL9	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	CRCT1	Homo sapiens	Q9UGL9	Y2H Array	32296183
Intra	MACO1	Q8N5G2	CRCT1	Homo sapiens	Q9UGL9	Validated Y2H	32296183
Intra	MACO1	Q8N5G2	LINGO1	Homo sapiens	Q96FE5	Validated Y2H	32296183
Intra	MACO1	Q8N5G2	LINGO1	Homo sapiens	Q96FE5	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	SMCP	Homo sapiens	P49901	Y2H Prey Pooling	32296183
Intra	MACO1	Q8N5G2	SMCP	Homo sapiens	P49901	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mitochondrial Complex Iii Deficiency	Complex 3 Mitochondrial Respiratory Chain Deficiency Isolated Coq-Cytochrome C Reductase Deficiency Ubiquinone-Cytochrome C Oxidoreductase Deficiency
Alkhurma Hemorrhagic Fever	Alkhumra Haemorrhagic Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07944	MACO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MACO1	VGNC	VGNC:100007
Felis catus	MACO1	VGNC	VGNC:63359
Mus musculus	MACO1	MGD	MGI:1913396
Bos taurus	MACO1	VGNC	VGNC:36098
Canis familiaris	MACO1	VGNC	VGNC:47589
Rattus norvegicus	MACO1	RGD	RGD:1561685
Others	MACO1	NCBI