1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

ACY-957 

Cat. No.: HY-104008
Handling Instructions

ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.

For research use only. We do not sell to patients.

ACY-957 Chemical Structure

ACY-957 Chemical Structure

CAS No. : 1609389-52-7

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5 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.

IC50 & Target[1]

HDAC1

7 nM (IC50)

HDAC2

18 nM (IC50)

HDAC3

1300 nM (IC50)

In Vitro

ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 has an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.3281 mL 11.6404 mL 23.2807 mL
5 mM 0.4656 mL 2.3281 mL 4.6561 mL
10 mM 0.2328 mL 1.1640 mL 2.3281 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

429.54

Formula

C₂₄H₂₃N₅OS

CAS No.

1609389-52-7

SMILES

O=C(C1=CC=C2N=C(N3CCNCC3)C=CC2=C1)NC4=CC(C5=CC=CS5)=CC=C4N

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
ACY-957
Cat. No.:
HY-104008
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