1609389-52-7
1609389-52-7
Chemical Structure
ACY-957
- CAS No.: 1609389-52-7
- Formula:C24H23N5OS
- Molecular Weight:429.54
IUPAC Name: N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide
InChIKey: VURDNNVAYZDGDK-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2N=C(N3CCNCC3)C=CC2=C1)NC4=CC(C5=CC=CS5)=CC=C4N
Biological Activity: ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ACY-957 | 99.63% | ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. | ||||||||||||||||||||
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ACY-957 (Standard) | ≥98% | ACY-957 (Standard) is the analytical standard of ACY-957 (HY-104008). This product is intended for research and analytical applications. ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.62
HY-124792MRLB-223 -
Similarity Score 0.61
HY-100719RBRD-6929 (Standard) -
Similarity Score 0.60
HY-124337BG48 -
Similarity Score 0.59
HY-139650HDAC1/2-IN-3 -
Similarity Score 0.58
HY-173160HDAC1-IN-10 -
Similarity Score 0.54
HY-141889MLKL-IN-2 -
Similarity Score 0.54
HY-117583ABG47 -
Similarity Score 0.52
HY-1371616-Nitroquipazine -
Similarity Score 0.51
HY-124053BRD2492 -
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