2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC3/6-IN-2

HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin.

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HDAC3/6-IN-2 Chemical Structure

HDAC3/6-IN-2 Chemical Structure

CAS No. : 2417510-17-7

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HDAC3/6-IN-2 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].

IC50 & Target

HDAC6

0.368 μM (IC50)

HDAC3

0.635 μM (IC50)

HDAC1

2.512 μM (IC50)

HDAC2

4.830 μM (IC50)

Molecular Weight

822.09

Formula

C49H67N5O6
CAS No.
SMILES

O=C(NC1=CC=C(N2CCN(C([C@](CC[C@]3(C)CC[C@@]4(C)[C@]5(C)CCC6C(C)(C)C(C(C#N)=C[C@]6(C)C57)=O)(C)C[C@@]3([H])C4=CC7=O)=O)CC2)C=C1)CCCCCCC(NO)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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HDAC3/6-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC3/6-IN-22417510-17-7HDACApoptosisHistone deacetylasesHL-60 cellsPC-3 cells18β-glycyrrhetinic acid (GA)antitumorconjugatecytotoxic agentCDODA-MeSAHAInhibitorinhibitorinhibit

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