HDAC3/6-IN-2
Based on 1 publication(s) in Google Scholar
HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin.
For research use only. We do not sell to patients.
- CAS No.: 2417510-17-7
- Formula: C49H67N5O6
- Molecular Weight:822.09
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) HDAC3/6-IN-2
More
Biological Activity
|
HDAC6 0.368 μM (IC50) |
HDAC3 0.635 μM (IC50) |
HDAC1 2.512 μM (IC50) |
HDAC2 4.830 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
0.37 μM
Compound: 15
|
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition after 72 hrs by trypan blue staining based cell counting assay
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition after 72 hrs by trypan blue staining based cell counting assay
|
[PMID: 31883490] |
| PC-3 | IC50 |
0.47 μM
Compound: 15
|
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 96 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 96 hrs by MTT assay
|
[PMID: 31883490] |
Chemical Information
-
CAS No. 2417510-17-7
-
Molecular Weight 822.09
-
Formula C49H67N5O6
-
SMILES
O=C(NC1=CC=C(N2CCN(C([C@](CC[C@]3(C)CC[C@@]4(C)[C@]5(C)CCC6C(C)(C)C(C(C#N)=C[C@]6(C)C57)=O)(C)C[C@@]3([H])C4=CC7=O)=O)CC2)C=C1)CCCCCCC(NO)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC3/6-IN-2 Related Classifications
HY-133147 Related Classifications
Powered by Bioz