1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. HDAC
    Apoptosis
  3. HDAC3/6-IN-2

HDAC3/6-IN-2 

Cat. No.: HY-133147
Handling Instructions

HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin.

For research use only. We do not sell to patients.

HDAC3/6-IN-2 Chemical Structure

HDAC3/6-IN-2 Chemical Structure

CAS No. : 2417510-17-7

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Description

HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].

IC50 & Target

HDAC6

0.368 μM (IC50)

HDAC3

0.635 μM (IC50)

HDAC1

2.512 μM (IC50)

HDAC2

4.830 μM (IC50)

Molecular Weight

822.09

Formula

C49H67N5O6

CAS No.
SMILES

O=C(NC1=CC=C(N2CCN(C([[email protected]](CC[[email protected]]3(C)CC[[email protected]@]4(C)[[email protected]]5(C)CCC6C(C)(C)C(C(C#N)=C[[email protected]]6(C)C57)=O)(C)C[[email protected]@]3([H])C4=CC7=O)=O)CC2)C=C1)CCCCCCC(NO)=O

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HDAC3/6-IN-2
Cat. No.:
HY-133147
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