EGFR/HDAC-IN-1
EGFR/HDAC-IN-1 (Compound 22c2) is a potent dual inhibitor of epidermal growth factor receptor (EGFR) and histone deacetylase (HDAC) with IC50 values of 4.81 nM, 119.4 nM and 354.8 nM for EGFR, HDAC1 and HDAC3, respectively. EGFR/HDAC-IN-1 blocks the EGFR signaling pathway and affects the histone acetylation status, thereby inhibiting tumor cell proliferation. EGFR/HDAC-IN-1 is promising for research of non-small cell lung cancer (NSCLC).
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- Formule: C22H23ClN4O5
- Masse moléculaire:458.89
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
IC50 & Target
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HDAC1 119.4 nM (IC50) |
HDAC3 354.8 nM (IC50) |
Chemical Information
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Masse moléculaire 458.89
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Formule C22H23ClN4O5
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SMILES
O=C(NO)CCCCCOC1=C2C(OCCO2)=C3C(NC4=CC(Cl)=CC=C4)=NC=NC3=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/HDAC-IN-1 Related Classifications
HY-173520 Related Classifications
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