EGFR/HDAC-IN-1
EGFR/HDAC-IN-1 (Compound 22c2) is a potent dual inhibitor of epidermal growth factor receptor (EGFR) and histone deacetylase (HDAC) with IC50 values of 4.81 nM, 119.4 nM and 354.8 nM for EGFR, HDAC1 and HDAC3, respectively. EGFR/HDAC-IN-1 blocks the EGFR signaling pathway and affects the histone acetylation status, thereby inhibiting tumor cell proliferation. EGFR/HDAC-IN-1 is promising for research of non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- Formula: C22H23ClN4O5
- Molecular Weight:458.89
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All EGFR Isoforms
More
Biological Activity
|
HDAC1 119.4 nM (IC50) |
HDAC3 354.8 nM (IC50) |
Chemical Information
-
Molecular Weight 458.89
-
Formula C22H23ClN4O5
-
SMILES
O=C(NO)CCCCCOC1=C2C(OCCO2)=C3C(NC4=CC(Cl)=CC=C4)=NC=NC3=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/HDAC-IN-1 Related Classifications
HY-173520 Related Classifications
Powered by Bioz