1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

AES-135 

Cat. No.: HY-114483
Handling Instructions

AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50s of 654, 190, and 636 nM, respectively. Anti-tumor activity.

For research use only. We do not sell to patients.

AES-135 Chemical Structure

AES-135 Chemical Structure

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50s of 654, 190, and 636 nM, respectively. Anti-tumor activity[1].

IC50 & Target[1]

HDAC6

190 nM (IC50)

HDAC11

636 nM (IC50)

HDAC3

654 nM (IC50)

References
Molecular Weight

693.66

Formula

C₃₃H₂₉F₆N₃O₅S

SMILES

CC(C)(C)C1=CC=C(CN(C(CN(CC2=C(F)C(F)=C(F)C(F)=C2F)S(=O)(C3=CC=C(F)C=C3)=O)=O)C4=CC=C(C(NO)=O)C=C4)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
AES-135
Cat. No.:
HY-114483
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AES-135

Cat. No.: HY-114483