2361659-61-0

AES-135 Chemical Structure
2361659-61-0

Chemical Structure

AES-135

  • CAS No.: 2361659-61-0
  • Formula:C33H29F6N3O5S
  • Molecular Weight:693.66

IUPAC Name: 4-(N-(4-(tert-butyl)benzyl)-2-((4-fluoro-N-((perfluorophenyl)methyl)phenyl)sulfonamido)acetamido)-N-hydroxybenzamide

InChIKey: LTRKEOBJRDKIHB-UHFFFAOYSA-N

SMILES: CC(C)(C)C1=CC=C(CN(C(CN(CC2=C(F)C(F)=C(F)C(F)=C2F)S(=O)(C3=CC=C(F)C=C3)=O)=O)C4=CC=C(C(NO)=O)C=C4)C=C1

Biological Activity: AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM[1].

Cat. No. Nom du produit Pureté Description Pricing
HY-114483 		AES-135 98.68% AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM.
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