1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC
  3. SR-4370

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.

For research use only. We do not sell to patients.

SR-4370 Chemical Structure

SR-4370 Chemical Structure

CAS No. : 1816294-67-3

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 132 In-stock
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10 mg USD 190 In-stock
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50 mg USD 530 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.

IC50 & Target[1]

HDAC3

6 nM (IC50)

HDAC1

130 nM (IC50)

HDAC2

580 nM (IC50)

HDAC8

2300 nM (IC50)

HDAC6

3400 nM (IC50)

In Vitro

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 is cytotoxic to the breast cancer cells (MDA-MB-231), with an IC50 of 12.6 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

304.33

Formula

C17H18F2N2O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C2=CC=CC(F)=C2F)C=C1)NNCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (492.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2859 mL 16.4295 mL 32.8591 mL
5 mM 0.6572 mL 3.2859 mL 6.5718 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2859 mL 16.4295 mL 32.8591 mL 82.1477 mL
5 mM 0.6572 mL 3.2859 mL 6.5718 mL 16.4295 mL
10 mM 0.3286 mL 1.6430 mL 3.2859 mL 8.2148 mL
15 mM 0.2191 mL 1.0953 mL 2.1906 mL 5.4765 mL
20 mM 0.1643 mL 0.8215 mL 1.6430 mL 4.1074 mL
25 mM 0.1314 mL 0.6572 mL 1.3144 mL 3.2859 mL
30 mM 0.1095 mL 0.5477 mL 1.0953 mL 2.7383 mL
40 mM 0.0821 mL 0.4107 mL 0.8215 mL 2.0537 mL
50 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.6430 mL
60 mM 0.0548 mL 0.2738 mL 0.5477 mL 1.3691 mL
80 mM 0.0411 mL 0.2054 mL 0.4107 mL 1.0268 mL
100 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.8215 mL
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SR-4370 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SR-4370
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HY-111400
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