1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

SR-4370 

Cat. No.: HY-111400 Purity: 98.33%
Handling Instructions

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.

For research use only. We do not sell to patients.

SR-4370 Chemical Structure

SR-4370 Chemical Structure

CAS No. : 1816294-67-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 154 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.

IC50 & Target[1]

HDAC3

6 nM (IC50)

HDAC1

130 nM (IC50)

HDAC2

580 nM (IC50)

HDAC8

2300 nM (IC50)

HDAC6

3400 nM (IC50)

In Vitro

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 is cytotoxic to the breast cancer cells (MDA-MB-231), with an IC50 of 12.6 μM[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.2859 mL 16.4295 mL 32.8591 mL
5 mM 0.6572 mL 3.2859 mL 6.5718 mL
10 mM 0.3286 mL 1.6430 mL 3.2859 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

304.33

Formula

C₁₇H₁₈F₂N₂O

CAS No.

1816294-67-3

SMILES

O=C(C1=CC=C(C2=CC=CC(F)=C2F)C=C1)NNCCCC

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 150 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
SR-4370
Cat. No.:
HY-111400
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