2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC8-IN-3

HDAC8-IN-3 (compound P19) is a potent HDAC8 inhibitor with IC50 value of 9.3 μM and produces thermal stabilization. HDAC8-IN-3 has cytotoxicity and induces apoptosis in leukemic cell lines.

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HDAC8-IN-3 Chemical Structure

HDAC8-IN-3 Chemical Structure

CAS No. : 2432825-93-7

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HDAC8-IN-3 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC8-IN-3 (compound P19) is a potent HDAC8 inhibitor with IC50 value of 9.3 μM and produces thermal stabilization. HDAC8-IN-3 has cytotoxicity and induces apoptosis in leukemic cell lines[1].

IC50 & Target[1]

HDAC8

9.3 μM (IC50)

HDAC6

17 μM (IC50)

HDAC2

41 μM (IC50)

HDAC1

＞50 μM (IC50)

HDAC3

＞50 μM (IC50)

HDAC4

＞50 μM (IC50)

HDAC5

＞50 μM (IC50)

HDAC8

＞50 μM (IC50)

In Vitro

HDAC8-IN-3 (compound P19) (5-200 μM, 48 hours; HEK293T cells) has cytotoxicity in leukemic cell lines[1].
HDAC8-IN-3 (compound P19) (50 μM) inhibits glucose transporter 1 (GLUT1)-mediated glucose transport by down-regulating GLUT1 expression (IC50 = 28.2 μM)[1].
HDAC8-IN-3 (compound P19) (79.9 μM; 24 hours) can induce apoptotic death in the CEM cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC8-IN-3 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: K562, KCL22 and CEM leukemia cells.
Concentration: 50 μM
Incubation Time: 48 hours
Result: Inhibited with IC50 values of 79.9, 85.4 and 43.2 μM for CEM, K562 and KCL22 cells, respectively.

Apoptosis Analysis[1]

Cell Line: CEM cells
Concentration: 79.9 μM
Incubation Time: 24 hours
Result: The percentage of apoptotic cells was recorded as 60.97%.
Molecular Weight

396.44

Formula

C18H12N4O3S2
CAS No.
SMILES

O=C(NC1=NC2=CC=CC=C2S1)CN(C/3=O)C(SC3=C\C4=NC=CC=C4)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC8-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC8-IN-32432825-93-7HDACApoptosisHistone deacetylasesGLUTLeukemiaapoptosisInhibitorinhibitorinhibit

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