FNDR-20123 free base
Based on 1 publication(s) in Google Scholar
FNDR-20123 free base is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations.
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- CAS No.: 1267502-34-0
- Formule: C21H23N5O2
- Masse moléculaire:377.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) FNDR-20123 free base
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Activité biologique
Description
IC50 & Target
[1]|
human HDAC 3 nM (IC50) |
Plasmodium HDAC 31 nM (IC50) |
HDAC1 25 nM (IC50) |
HDAC2 29 nM (IC50) |
HDAC3 2 nM (IC50) |
HDAC6 11 nM (IC50) |
HDAC8 282 nM (IC50) |
Plasmodium |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:P. falciparum Pf3D70087/N9 in NODscidIL2Rγnull mice (engrafted with human erythrocytes)[1]
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Dosage:10 and 50 mg/kg
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Administration:P.o.; bw for 4 days
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Result:Resulted in a significant reduction in parasitaemia with 6.5% and 2.57% parasitaemia at 10 and 50 mg/kg, respectively.
Chemical Information
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CAS No. 1267502-34-0
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Masse moléculaire 377.44
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Formule C21H23N5O2
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SMILES
O=C(NO)C1=CC=C(CN2N=NC(C3=CC=C(CN4CCCC4)C=C3)=C2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FNDR-20123 free base Related Classifications
HY-131708 Related Classifications
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