DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a) is a DNMT1/HDAC dual inhibitor (HDAC1:IC50=0.05 μM), HDAC1 is a major HDAC isoform that interacts with DNMT1 in multiple protein complexes for transcriptional silencing of TSGs. DNMT1/HDAC-IN-1 can reshape the tumor immune microenvironment and induce tumor regression, and effectively reverse cancer-specific epigenetic abnormalities.
For research use only. We do not sell to patients.
- CAS No.: 3104460-09-2
- Formula: C33H35N7O3S
- Molecular Weight:609.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All DNA Methyltransferase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
HDAC1 0.05 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
0.36 μM
Compound: (R)-23a
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Inhibition of cell viability in human HL-60 cells incubated for 4 days by CCK8 assay
Inhibition of cell viability in human HL-60 cells incubated for 4 days by CCK8 assay
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[PMID: 39264152] |
| Kasumi 1 | IC50 |
0.41 μM
Compound: (R)-23a
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Inhibition of cell viability in human Kasumi 1 cells incubated for 4 days by CCK8 assay
Inhibition of cell viability in human Kasumi 1 cells incubated for 4 days by CCK8 assay
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[PMID: 39264152] |
| MV4-11 | IC50 |
0.32 μM
Compound: (R)-23a
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Inhibition of cell viability in human MV4-11 cells incubated for 4 days by CCK8 assay
Inhibition of cell viability in human MV4-11 cells incubated for 4 days by CCK8 assay
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[PMID: 39264152] |
Chemical Information
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CAS No. 3104460-09-2
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Molecular Weight 609.74
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Formula C33H35N7O3S
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SMILES
CCC1=C(C(S[C@H](C2=CC=CC=C2)C(N)=O)=NC(N3CCC(CC3)CNCC4=CC=C(C=C4)/C=C/C(NO)=O)=C1C#N)C#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DNMT1/HDAC-IN-1 Related Classifications
HY-168088 Related Classifications
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