country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-168088

Copy Link Print Information

DNMT1/HDAC-IN-1

DNMT1/HDAC-IN-1 (compound (R)-23a) is a DNMT1/HDAC dual inhibitor (HDAC1:IC₅₀=0.05 μM), HDAC1 is a major HDAC isoform that interacts with DNMT1 in multiple protein complexes for transcriptional silencing of TSGs. DNMT1/HDAC-IN-1 can reshape the tumor immune microenvironment and induce tumor regression, and effectively reverse cancer-specific epigenetic abnormalities.

For research use only. We do not sell to patients.

CAS No.: 3104460-09-2
Formula: C₃₃H₃₅N₇O₃S
Molecular Weight:609.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DNMT1/HDAC-IN-1 Chemical Structure

CAS No.: 3104460-09-2

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HDAC1

0.05 μM (IC₅₀)

All HDAC Isoforms :

All DNA Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	0.36 μM Compound: (R)-23a	Inhibition of cell viability in human HL-60 cells incubated for 4 days by CCK8 assay Inhibition of cell viability in human HL-60 cells incubated for 4 days by CCK8 assay	[PMID: 39264152]
Kasumi 1	IC₅₀	0.41 μM Compound: (R)-23a	Inhibition of cell viability in human Kasumi 1 cells incubated for 4 days by CCK8 assay Inhibition of cell viability in human Kasumi 1 cells incubated for 4 days by CCK8 assay	[PMID: 39264152]
MV4-11	IC₅₀	0.32 μM Compound: (R)-23a	Inhibition of cell viability in human MV4-11 cells incubated for 4 days by CCK8 assay Inhibition of cell viability in human MV4-11 cells incubated for 4 days by CCK8 assay	[PMID: 39264152]

Chemical Information

CAS No. 3104460-09-2
Molecular Weight 609.74
Formula C₃₃H₃₅N₇O₃S
SMILES

CCC1=C(C(S[C@H](C2=CC=CC=C2)C(N)=O)=NC(N3CCC(CC3)CNCC4=CC=C(C=C4)/C=C/C(NO)=O)=C1C#N)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chang Y, et al. Development of a First-in-Class DNMT1/HDAC Inhibitor with Improved Therapeutic Potential and Potentiated Antitumor Immunity[J]. Journal of Medicinal Chemistry, 2024. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

DNMT1/HDAC-IN-1

All HDAC Isoforms

All DNA Methyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DNMT1/HDAC-IN-1 Related Classifications

HY-168088 Related Classifications