3104460-09-2
Chemical Structure
DNMT1/HDAC-IN-1
- CAS No.: 3104460-09-2
- Formula:C33H35N7O3S
- Molecular Weight:609.74
InChIKey: ODDZJSGIPIWFAU-SHPZBJSMSA-N
SMILES: CCC1=C(C(S[C@H](C2=CC=CC=C2)C(N)=O)=NC(N3CCC(CC3)CNCC4=CC=C(C=C4)/C=C/C(NO)=O)=C1C#N)C#N
Biological Activity: DNMT1/HDAC-IN-1 (compound (R)-23a) is a DNMT1/HDAC dual inhibitor (HDAC1:IC50=0.05 μM), HDAC1 is a major HDAC isoform that interacts with DNMT1 in multiple protein complexes for transcriptional silencing of TSGs. DNMT1/HDAC-IN-1 can reshape the tumor immune microenvironment and induce tumor regression, and effectively reverse cancer-specific epigenetic abnormalities[1].
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DNMT1/HDAC-IN-1 | DNMT1/HDAC-IN-1 (compound (R)-23a) is a DNMT1/HDAC dual inhibitor (HDAC1:IC50=0.05 μM), HDAC1 is a major HDAC isoform that interacts with DNMT1 in multiple protein complexes for transcriptional silencing of TSGs. DNMT1/HDAC-IN-1 can reshape the tumor immune microenvironment and induce tumor regression, and effectively reverse cancer-specific epigenetic abnormalities. | |||||||||||||||||||||
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Keywords
