3104460-09-2
Chemical Structure
DNMT1/HDAC-IN-1
- CAS No.: 3104460-09-2
- Formula:C33H35N7O3S
- Molecular Weight:609.74
InChIKey: ODDZJSGIPIWFAU-SHPZBJSMSA-N
SMILES: CCC1=C(C(S[C@H](C2=CC=CC=C2)C(N)=O)=NC(N3CCC(CC3)CNCC4=CC=C(C=C4)/C=C/C(NO)=O)=C1C#N)C#N
Biological Activity: DNMT1/HDAC-IN-1 is a dual DNMT1/HDAC inhibitor with IC50 values of 0.32 μM and 0.06 μM, respectively. DNMT1/HDAC-IN-1 inhibits DNA methyltransferase activity, promotes proteasome-dependent degradation of DNMT1, and inhibits HDAC catalytic activity. DNMT1/HDAC-IN-1 reactivates epigenetically silenced tumor suppressor genes, downregulates oncogene expression, and induces cell cycle arrest and apoptosis. DNMT1/HDAC-IN-1 can be used for research on acute myeloid leukemia and colorectal cancer[1].
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DNMT1/HDAC-IN-1 | 99.45% | DNMT1/HDAC-IN-1 is a dual DNMT1/HDAC inhibitor with IC50 values of 0.32 μM and 0.06 μM, respectively. DNMT1/HDAC-IN-1 inhibits DNA methyltransferase activity, promotes proteasome-dependent degradation of DNMT1, and inhibits HDAC catalytic activity. DNMT1/HDAC-IN-1 reactivates epigenetically silenced tumor suppressor genes, downregulates oncogene expression, and induces cell cycle arrest and apoptosis. DNMT1/HDAC-IN-1 can be used for research on acute myeloid leukemia and colorectal cancer. | ||||||||||||||||||||
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