1. Cell Cycle/DNA Damage
    Epigenetics
    Metabolic Enzyme/Protease
  2. HDAC
    HSP
  3. HDAC6/HSP90-IN-1

HDAC6/HSP90-IN-1 

Cat. No.: HY-146293
Handling Instructions

HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice.

For research use only. We do not sell to patients.

HDAC6/HSP90-IN-1 Chemical Structure

HDAC6/HSP90-IN-1 Chemical Structure

CAS No. : 2411955-43-4

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1].

IC50 & Target

HDAC6

4.32 nM (IC50)

HSP90

46.8 nM (IC50)

HDAC3

1312 nM (IC50)

HDAC1

1878 nM (IC50)

HDAC8

3720 nM (IC50)

Molecular Weight

511.61

Formula

C28H37N3O6

CAS No.
SMILES

CC(C1=C(C=C(C(C(N2CC3=CC=C(C=C3C2)NC(CCCCCCCCC(NO)=O)=O)=O)=C1)O)O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
HDAC6/HSP90-IN-1
Cat. No.:
HY-146293
Quantity:
MCE Japan Authorized Agent: