HDAC6/HSP90-IN-1
HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice.
For research use only. We do not sell to patients.
- CAS No.: 2411955-43-4
- Formula: C28H37N3O6
- Molecular Weight:511.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
HDAC6 4.32 nM (IC50) |
HSP90 46.8 nM (IC50) |
HDAC3 1312 nM (IC50) |
HDAC1 1878 nM (IC50) |
HDAC8 3720 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
0.76 μM
Compound: 17
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Growth inhibition of human A549 cells incubated for 48 hrs by SRB assay
Growth inhibition of human A549 cells incubated for 48 hrs by SRB assay
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[PMID: 32058238] |
| NCI-H1975 | GI50 |
0.52 μM
Compound: 17
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Growth inhibition of human NCI-H1975 cells incubated for 48 hrs by SRB assay
Growth inhibition of human NCI-H1975 cells incubated for 48 hrs by SRB assay
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[PMID: 32058238] |
Chemical Information
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CAS No. 2411955-43-4
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Molecular Weight 511.61
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Formula C28H37N3O6
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SMILES
CC(C1=C(C=C(C(C(N2CC3=CC=C(C=C3C2)NC(CCCCCCCCC(NO)=O)=O)=O)=C1)O)O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6/HSP90-IN-1 Related Classifications
HY-146293 Related Classifications
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