HDAC3 degrader-1
HDAC3 degrader-1 (Compound Z8) is a selective HDAC3 degrader with a DC50 of 2.42 μM. HDAC3 degrader-1 has almost no effect on HDAC1, HDAC2, and HDAC6. HDAC3 degrader-1 inhibits the activation of the NLRP3 inflammasome and reduces the secretion of IL-1β and caspase-1. HDAC3 degrader-1 shows significant efficacy in septic shock and colitis models. HDAC3 degrader-1 can be used in anti-inflammatory research.
For research use only. We do not sell to patients.
- Formula: C36H48F2N2O2
- Molecular Weight:578.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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HDAC3 2.42 μM (DC50) |
Caspase-1 |
IL-1β |
NLRP3 |
Chemical Information
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Molecular Weight 578.78
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Formula C36H48F2N2O2
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SMILES
FC(CC1)(F)CCN1C([C@@]2(C)CC[C@]3(C)CC[C@@]4(C)[C@]5(C)CC[C@@]6([H])C(C)(C)C(C(C#N)=C[C@]6(C)C5=CC=C4[C@]3([H])C2)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC3 degrader-1 Related Classifications
HY-179682 Related Classifications
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