1. Cell Cycle/DNA Damage
    Epigenetics
    PROTAC
  2. HDAC
    PROTACs
  3. JPS016

JPS016 

Cat. No.: HY-145816
Handling Instructions

JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells.

For research use only. We do not sell to patients.

JPS016 Chemical Structure

JPS016 Chemical Structure

CAS No. : 2669785-77-5

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Description

JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Molecular Weight

898.12

Formula

C48H63N7O8S

CAS No.
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JPS016
Cat. No.:
HY-145816
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