2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC Epigenetic Reader Domain
  4. NB512

NB512 (compound 39a) is a dual inhibitor for BET and HDAC, which exhibits a efficient binding affinity with BRD4 bromodomains and HDAC1/2, with EC50s of 100-400 nM. NB512 exhibits an anti-proliferative activity towards cancer cells PaTu8988T and NMC.

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NB512

NB512 構造式

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NB512 関連抗体

Top Publications Citing Use of Products

HDAC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Epigenetic Reader Domain アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Brd BRPF1 BRPF2 BRPF3 BRD2 BRD3 BRD4 BRDT CECR2 BD1 BD2 BRD7 BRD9 BET BAZ

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製品説明

NB512 (compound 39a) is a dual inhibitor for BET and HDAC, which exhibits a efficient binding affinity with BRD4 bromodomains and HDAC1/2, with EC50s of 100-400 nM. NB512 exhibits an anti-proliferative activity towards cancer cells PaTu8988T and NMC[1].

IC50 & Target

HDAC2

0.1 μM (EC50)

HDAC1

0.11 μM (EC50)

BRD4 BD2

0.25 μM (EC50)

BRD4 BD1

0.36 μM (EC50)

HDAC3

13.6 μM (EC50)

体外実験

NB512 (1 μM) inihibits the deacetylation of histone H3 K9/K14, upregulates the BET targeting marker HEXIM1 and cell cycle regulator gene p57 in PaTu8988T in a dose-dependent manner[1].
NB512 (1 μM) exhibits an anti-proliferative activity towards PaTu8988T and NMC, with IC50s of 3.6 and 0.42 μM, respectively[1].
NB512 (1 μM) downregulates oncogenic transcription factors MYC and TP63 in NMC cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NB512 関連抗体

Western Blot Analysis[1]

Cell Line: PaTu8988T
Concentration: 0-1 μM
Incubation Time: 48 h
Result: Increased acetylated histone H3 K9/K14 in a dose-dependent manner.

RT-PCR[1]

Cell Line: PaTu8988T
Concentration: 0-1 μM
Incubation Time: 6 h
Result: Upregulated mRNA levels of HEXIM1 and p57 in a dose-dependent manner.
分子量

435.48

分子式

C26H21N5O2
SMILES

O=C(NC1=CC(C2=CC=CC=C2)=CC=C1N)C3=NC=C(C4=CN(C)C(C5=C4C=CN5)=O)C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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NB512 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NB512NB 512NB-512HDACEpigenetic Reader DomainHistone deacetylaseshistone deacetylasespancreatic cancerPaTu8988THEXIM1p57Inhibitorinhibitorinhibit

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製品名:
NB512
製品番号:
HY-163282
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