1. Cell Cycle/DNA Damage
    Epigenetics
    Neuronal Signaling
  2. HDAC
    Amyloid-β
    AChE
  3. HDAC6-IN-6

HDAC6-IN-6 

Cat. No.: HY-146679
Handling Instructions

HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against 1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity.

For research use only. We do not sell to patients.

HDAC6-IN-6 Chemical Structure

HDAC6-IN-6 Chemical Structure

CAS No. : 2413603-10-6

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Description

HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against 1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].

IC50 & Target

HDAC6

0.025 ± 0. μM (IC50)

HDAC1

0.34 ± 0.0 μM (IC50)

HDAC

0.55 ± 0.0 μM (IC50)

HDAC9

0.57 ± 0.0 μM (IC50)

HDAC7

0.65 ± 0.0 μM (IC50)

HDAC5

0.85 ± 0.0 μM (IC50)

HDAC3

1.22 ± 0.0 μM (IC50)

HDAC2

1.57 ± 0.0 μM (IC50)

HDAC4

2.24 ± 0.0 μM (IC50)

In Vitro

HDAC6-IN-6 (compound 6a) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 7.96 and 8 μM, respectively[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

329.35

Formula

C20H15N3O2

CAS No.
SMILES

O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=CC=C42)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
HDAC6-IN-6
Cat. No.:
HY-146679
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