HDAC6-IN-6
HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 2413603-10-6
- Formula: C20H15N3O2
- Molecular Weight:329.35
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
HDAC6 0.025 ± 0. μM (IC50) |
HDAC1 0.34 ± 0.0 μM (IC50) |
HDAC 0.55 ± 0.0 μM (IC50) |
HDAC9 0.57 ± 0.0 μM (IC50) |
HDAC7 0.65 ± 0.0 μM (IC50) |
HDAC5 0.85 ± 0.0 μM (IC50) |
HDAC3 1.22 ± 0.0 μM (IC50) |
HDAC2 1.57 ± 0.0 μM (IC50) |
HDAC4 2.24 ± 0.0 μM (IC50) |
HDAC6-IN-6 (compound 6a) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 7.96 and 8 μM, respectively[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2413603-10-6
-
Molecular Weight 329.35
-
Formula C20H15N3O2
-
SMILES
O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=CC=C42)NO
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz