2413603-10-6
2413603-10-6
Chemical Structure
HDAC6-IN-6
- CAS No.: 2413603-10-6
- Formula:C20H15N3O2
- Molecular Weight:329.35
IUPAC Name: 4-(acridin-9-ylamino)-N-hydroxybenzamide
InChIKey: HYCPLKOVNZFNAS-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=CC=C42)NO
Biological Activity: HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].
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HDAC6-IN-6 | HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity. | |||||||||||||||||||||
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References
Keywords
