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Cat. No.: HY-161154

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HDAC3-IN-3

HDAC3-IN-3 (compound 31) is a potent HDAC3 inhibitor. HDAC3-IN-3 has the potential for the research of cancer.

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CAS No.: 2170996-03-7
화학식: C₂₆H₂₂N₄O₂
분자량:422.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HDAC3-IN-3 Chemical Structure

CAS No.: 2170996-03-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

HDAC3-IN-3 (compound 31) is a potent HDAC3 inhibitor. HDAC3-IN-3 has the potential for the research of cancer^[1].

IC₅₀ & Target^[1]

HDAC3

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.53 μM Compound: 174	Cytotoxicity against human HCT-116 cells Cytotoxicity against human HCT-116 cells	[PMID: 34332400]
HCT-116	IC₅₀	0.78 μM Compound: 12f	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 29288941]
HepG2	IC₅₀	0.53 μM Compound: 12f	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 29288941]
HepG2	IC₅₀	0.53 μM Compound: 174	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 34332400]
Huh-7	IC₅₀	0.53 μM Compound: 174	Cytotoxicity against human Huh-7 cells Cytotoxicity against human Huh-7 cells	[PMID: 34332400]
Huh-7	IC₅₀	0.96 μM Compound: 12f	Antiproliferative activity against human HuH7 cells after 48 hrs by MTT assay Antiproliferative activity against human HuH7 cells after 48 hrs by MTT assay	[PMID: 29288941]
MCF7	IC₅₀	0.53 μM Compound: 174	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 34332400]
MCF7	IC₅₀	1.56 μM Compound: 12f	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 29288941]
SMMC-7721	IC₅₀	0.87 μM Compound: 12f	Antiproliferative activity against human SMMC7721 cells after 48 hrs by MTT assay Antiproliferative activity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 29288941]

Chemical Information

CAS No. 2170996-03-7
분자량 422.48
화학식 C₂₆H₂₂N₄O₂
SMILES

CC(C=C1)=CC=C1C2=NC(NCC3=CC=C(C(NO)=O)C=C3)=CC4=C2NC5=C4C=CC=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Patel P, et al. Hydroxamic acid derivatives as selective HDAC3 inhibitors: computer-aided drug design strategies. J Biomol Struct Dyn. 2024 Jan-Feb;42(1):362-383. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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HDAC3-IN-3

All HDAC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HDAC3-IN-3 Related Classifications

HY-161154 Related Classifications